Human Genetics and Cognitive Functions, Institut Pasteur, UMR 3571 CNRS, University Paris Diderot, Paris, France.
Precision Psychiatry and Social Physiology laboratory, CHU Ste-Justine Research Center, Department of Psychiatry, University of Montreal, Quebec, QC, Canada.
J Pineal Res. 2021 Apr;70(3):e12713. doi: 10.1111/jpi.12713. Epub 2021 Jan 11.
The human pineal gland regulates day-night dynamics of multiple physiological processes, especially through the secretion of melatonin. Using mass-spectrometry-based proteomics and dedicated analysis tools, we identify proteins in the human pineal gland and analyze systematically their variation throughout the day and compare these changes in the pineal proteome between control specimens and donors diagnosed with autism. Results reveal diverse regulated clusters of proteins with, among others, catabolic carbohydrate process and cytoplasmic membrane-bounded vesicle-related proteins differing between day and night and/or control versus autism pineal glands. These data show novel and unexpected processes happening in the human pineal gland during the day/night rhythm as well as specific differences between autism donor pineal glands and those from controls.
人类的松果体通过分泌褪黑素来调节昼夜节律的多种生理过程。本研究使用基于质谱的蛋白质组学和专用分析工具，鉴定了人类松果体中的蛋白质，并系统地分析了它们在一天中的变化，并比较了对照组和自闭症供体的松果体蛋白质组之间的这些变化。结果揭示了不同的受调控的蛋白质簇，其中包括代谢碳水化合物过程和细胞质膜结合囊泡相关蛋白，这些蛋白在昼夜和/或对照与自闭症松果体之间存在差异。这些数据显示了人类松果体在昼夜节律过程中发生的新的和意外的过程，以及自闭症供体松果体与对照组松果体之间的特定差异。
