过氧化物还原酶6在细胞信号传导中的作用
The Role of Peroxiredoxin 6 in Cell Signaling.
作者信息
Arevalo José A, Vázquez-Medina José Pablo
机构信息
Department of Integrative Biology, University of California, Berkeley, CA, 94705, USA.
出版信息
Antioxidants (Basel). 2018 Nov 24;7(12):172. doi: 10.3390/antiox7120172.
Abstract
Peroxiredoxin 6 (Prdx6, 1-cys peroxiredoxin) is a unique member of the peroxiredoxin family that, in contrast to other mammalian peroxiredoxins, lacks a resolving cysteine and uses glutathione and π glutathione S-transferase to complete its catalytic cycle. Prdx6 is also the only peroxiredoxin capable of reducing phospholipid hydroperoxides through its glutathione peroxidase (Gpx) activity. In addition to its peroxidase activity, Prdx6 expresses acidic calcium-independent phospholipase A₂ (aiPLA₂) and lysophosphatidylcholine acyl transferase (LPCAT) activities in separate catalytic sites. Prdx6 plays crucial roles in lung phospholipid metabolism, lipid peroxidation repair, and inflammatory signaling. Here, we review how the distinct activities of Prdx6 are regulated during physiological and pathological conditions, in addition to the role of Prdx6 in cellular signaling and disease.
摘要
过氧化物酶体增殖物激活受体6（Prdx6，1-半胱氨酸过氧化物酶）是过氧化物酶体增殖物激活受体家族的一个独特成员，与其他哺乳动物过氧化物酶体增殖物激活受体不同，它缺乏一个分解半胱氨酸，并利用谷胱甘肽和π谷胱甘肽S-转移酶来完成其催化循环。Prdx6也是唯一能够通过其谷胱甘肽过氧化物酶（Gpx）活性还原磷脂氢过氧化物的过氧化物酶体增殖物激活受体。除了其过氧化物酶活性外，Prdx6在不同的催化位点还表现出酸性钙非依赖性磷脂酶A₂（aiPLA₂）和溶血磷脂酰胆碱酰基转移酶（LPCAT）活性。Prdx6在肺磷脂代谢、脂质过氧化修复和炎症信号传导中起关键作用。在这里，我们除了综述Prdx6在细胞信号传导和疾病中的作用外，还回顾了Prdx6的不同活性在生理和病理条件下是如何被调节的。
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