Novick W M, Nusbaum M, Stein T P
Surgical Research Laboratories, Graduate Hospital, University of Pennsylvania, Philadelphia.
Surgery. 1988 Jan;103(1):99-106.
Energy expenditure before and after surgery was determined in seven patients by the doubly labeled water (2H218O) method (DLW). The values were compared with values obtained by respiratory gas exchange by means of a metabolic measuring cart (MMC). Patients were maintained on total parenteral nutrition before and after trauma. The principal finding was an increase in the rate of CO2 production of 11.9 +/- 5.0% after surgery. This corresponds to a 267 +/- increase in energy expenditure (p less than 0.05). No trauma-associated change in energy expenditure was found with the MMC. The correlation of preoperative values from MMC and DLW was not statistically significant (r = 0.25), nor was the correlation of MMC and the Harris-Benedict equation, but the correlation of DLW with Harris-Benedict equation was statistically significant (r = 0.73, p less than 0.05). We suggest that the discrepancy is because the DLW method measures the cumulative energy expenditure over a period, whereas the MMC gives a "spot" measurement.
采用双标记水（2H218O）法（DLW）测定了7例患者手术前后的能量消耗。将这些值与通过代谢测量推车（MMC）进行呼吸气体交换所获得的值进行比较。患者在创伤前后均接受全胃肠外营养。主要发现是术后二氧化碳产生率增加了11.9±5.0%。这相当于能量消耗增加了267±（此处原文似乎有误，可能是267±某个值）（p<0.05）。使用MMC未发现与创伤相关的能量消耗变化。MMC术前值与DLW的相关性无统计学意义（r = 0.25），MMC与哈里斯-本尼迪克特方程的相关性也无统计学意义，但DLW与哈里斯-本尼迪克特方程的相关性有统计学意义（r = 0.73，p<0.05）。我们认为差异的原因是DLW法测量的是一段时间内的累积能量消耗，而MMC给出的是“即时”测量值。
