Faculty of Health Sciences, Centre for Toxicology and Health Risk Studies, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Pantai Premier Pathology SDN BHD, Reference Specialised Laboratory, Pantai Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
Rev Med Virol. 2021 Sep;31(5):1-9. doi: 10.1002/rmv.2207. Epub 2020 Dec 26.
Understanding the molecules that are essential for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) entry can provide insights into viral infection and dissemination. Recently, it has been identified from several studies that angiotensin-converting enzyme 2 receptor and transmembrane serine protease 2 are the main entry molecules for the SARS-CoV-2, which produced the pandemic of Covid-19. However, additional evidence showed several other viral receptors and cellular proteases that are also important in facilitating viral entry and transmission in the target cells. In this review, we summarized the types of SARS-CoV-2 entry molecules and discussed their crucial roles for virus binding, protein priming and fusion to the cellular membrane important for SARS-CoV-2 infection.
了解严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）进入所需的分子，可以深入了解病毒感染和传播。最近，有几项研究表明，血管紧张素转换酶 2 受体和跨膜丝氨酸蛋白酶 2 是导致 COVID-19 大流行的 SARS-CoV-2 的主要进入分子。然而，其他一些病毒受体和细胞蛋白酶的证据也表明，它们在促进病毒进入和在靶细胞中传播方面也很重要。在这篇综述中，我们总结了 SARS-CoV-2 进入分子的类型，并讨论了它们在病毒结合、蛋白引发和融合到细胞膜中的关键作用，这些过程对 SARS-CoV-2 感染很重要。
