da Silva Rafaela Pires, Thomé Bibiana Liberman, da Souza Ana Paula Duarte
Laboratory of Clinical and Experimental Immunology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90619-900, Brazil.
Biology (Basel). 2023 Sep 9;12(9):1223. doi: 10.3390/biology12091223.
Viral respiratory tract infections are a significant public health concern, particularly in children. RSV is a prominent cause of lower respiratory tract infections among infants, whereas SARS-CoV-2 has caused a global pandemic with lower overall severity in children than in adults. In this review, we aimed to compare the innate and adaptive immune responses induced by RSV and SARS-CoV-2 to better understand differences in the pathogenesis of infection. Some studies have demonstrated that children present a more robust immune response against SARS-CoV-2 than adults; however, this response is dissimilar to that of RSV. Each virus has a distinctive mechanism to escape the immune response. Understanding the mechanisms underlying these differences is crucial for developing effective treatments and improving the management of pediatric respiratory infections.
病毒性呼吸道感染是一个重大的公共卫生问题，在儿童中尤为如此。呼吸道合胞病毒（RSV）是婴儿下呼吸道感染的一个主要病因，而严重急性呼吸综合征冠状病毒2（SARS-CoV-2）已引发全球大流行，儿童感染后的总体严重程度低于成人。在本综述中，我们旨在比较RSV和SARS-CoV-2诱导的先天性和适应性免疫反应，以更好地了解感染发病机制的差异。一些研究表明，儿童对SARS-CoV-2的免疫反应比成人更强；然而，这种反应与RSV不同。每种病毒都有独特的逃避免疫反应的机制。了解这些差异背后的机制对于开发有效的治疗方法和改善儿科呼吸道感染的管理至关重要。
