Department of Gastroenterology, University Hospital of Split, Split, Croatia.
Department of Pharmacy, University of Split School of Medicine, Split, Croatia.
Helicobacter. 2021 Apr;26(2):e12775. doi: 10.1111/hel.12775. Epub 2020 Dec 23.
Helicobacter pylori (H pylori) eradication is becoming increasingly difficult. The aim of our study was to determine the knowledge of current guidelines and attitude in the diagnosis and treatment of H pylori infection in primary care physicians (PCPs) and medical students in Croatia.
A study was conducted among PCPs and medical students to evaluate adherence to Maastricht V consensus guidelines. Questionnaire was distributed by e-mail to 2338 PCPs offices in Croatia and to the medical students from the University of Split School of Medicine. Responses were collected electronically from June 22 to August 22, 2020.
Two hundred forty-nine PCPs and 169 medical students were included in the study. Bismuth or non-bismuth-based quadruple therapy as first-line treatment for H pylori was the choice of 4.8% of PCPs and 13% of students, while 66.3% PCPs and 79.9% students would choose clarithromycin-based triple therapy. Bismuth-based quadruple therapy was the most preferred second line of treatment for 45.4% of PCPs and 34.9% of students. Only 2.8% PCPs and 7.1% of students would correctly recommend first and second line of treatment for H. pylori infection. A larger proportion of students than PCPs would prefer C13-urea breath test (50.3% vs 6.4%). Only 59.0% PCPs would treat for H pylori in all patients including the asymptomatic ones. Students more frequently recognized the link between H pylori and gastric cancer compared with PCPs (92.9% vs 73.5%).
Primary care physicians and medical students' knowledge of H pylori guidelines are insufficient in Croatia and ask for additional training.
幽门螺杆菌（H pylori）的根除越来越困难。我们的研究目的是确定克罗地亚初级保健医生（PCPs）和医学生对当前指南在 H pylori 感染诊断和治疗中的认识和态度。
对 PCPs 和医学生进行了一项研究，以评估他们对马斯特里赫特 V 共识指南的依从性。调查问卷通过电子邮件分发给克罗地亚的 2338 个 PCPs 办公室和斯普利特大学医学院的医学生。2020 年 6 月 22 日至 8 月 22 日，通过电子方式收集了回复。
研究共纳入 249 名 PCPs 和 169 名医学生。铋剂或非铋剂四联疗法作为 H pylori 的一线治疗选择，4.8%的 PCPs 和 13%的学生选择，而 66.3%的 PCPs 和 79.9%的学生选择克拉霉素三联疗法。铋剂四联疗法是 45.4%的 PCPs 和 34.9%的学生最愿意选择的二线治疗方案。只有 2.8%的 PCPs 和 7.1%的学生能正确推荐 H. pylori 感染的一线和二线治疗方案。与 PCPs 相比，更多的学生愿意选择 C13-尿素呼气试验（50.3%比 6.4%）。只有 59.0%的 PCPs 会对所有患者（包括无症状患者）进行 H pylori 治疗。与 PCPs 相比，学生更频繁地认识到 H pylori 与胃癌之间的联系（92.9%比 73.5%）。
克罗地亚的 PCPs 和医学生对 H pylori 指南的认识不足，需要额外的培训。
