Department of Biological Sciences, Sunway University, Bandar Sunway, Malaysia.
Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
J Appl Microbiol. 2021 Sep;131(3):1039-1055. doi: 10.1111/jam.14981. Epub 2021 Jan 11.
Cancer is a prominent cause of morbidity and mortality worldwide, in spite of advances in therapeutic interventions and supportive care. In 2018 alone, there were 18·1 million new cancer cases and 9·6 million deaths indicating the need for novel anticancer agents. Plant-based products have often been linked with protective effects against communicable and non-communicable diseases. Recently, we have shown that animals such as crocodiles thrive in polluted environments and are often exposed to carcinogenic agents, but still benefit from prolonged lifespan. The protective mechanisms shielding them from cancer could be attributed to the immune system, and/or it is possible that their gut microbiota produce anticancer molecules. In support, several lines of evidence suggest that gut microbiota plays a critical role in the physiology of its host. Here, we reviewed the available literature to assess whether the gut microbiota of animals thriving in polluted environment possess anticancer molecules.
癌症是全世界发病率和死亡率的主要原因，尽管治疗干预和支持性护理取得了进展。仅在 2018 年，就有 1810 万例新癌症病例和 960 万人死亡，这表明需要新型抗癌药物。植物来源的产品通常与预防传染病和非传染性疾病的保护作用有关。最近，我们已经表明，鳄鱼等动物在污染环境中茁壮成长，经常接触致癌物质，但仍受益于延长的寿命。保护它们免受癌症侵害的机制可能归因于免疫系统，或者它们的肠道微生物群可能产生抗癌分子。有证据表明，肠道微生物群在宿主生理学中起着关键作用。在这里，我们回顾了现有文献，以评估在污染环境中茁壮成长的动物的肠道微生物群是否具有抗癌分子。
