Toll 样受体 4 和 2 基因多态性与强直性脊柱炎易感性的关联：荟萃分析。

Associations of toll-like receptor 4 and 2 gene polymorphisms with susceptibility to ankylosing spondylitis: A meta-analysis.

机构信息

Department of Spine Surgery, Xinjiang Medical University First Affiliated Hospital, Urumqi, China.

出版信息

Int J Immunogenet. 2021 Apr;48(2):219-228. doi: 10.1111/iji.12524. Epub 2020 Dec 23.

DOI:10.1111/iji.12524

PMID:33369094

Abstract

BACKGROUND

The published evidences on the correlations of toll-like receptor 4 (TLR4) and TLR9 gene polymorphisms and ankylosing spondylitis (AS) were conflicting. The purpose of this study was to investigate whether TLR4 and TLR9 gene polymorphisms conferred susceptibility to AS through a meta-analysis approach.

METHODS

Databases of PubMed, Web of Science, EMBASE, Cochrane Library, CNKI and Wanfang were retrieved for relevant publications up to 20 June 2020. Study quality was assessed based on Newcastle-Ottawa scale (NOS). Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to judge the associations.

RESULTS

Totally, 13 articles with 3,055 AS cases and 4,238 controls were incorporated into this meta-analysis, and four most widely reported polymorphisms (TLR4-rs4986790, TLR4-rs4986791, TLR9-rs55704465 and TLR9-rs187084) were analysed. All included studies were in high quality. The pooled data did not support any significant association between the four studied polymorphisms and AS susceptibility.

CONCLUSIONS

The present meta-analysis suggests there is no significant association between TLR4-rs4986790, TLR4-rs4986791, TLR9-rs55704465 and TLR9-rs187084 polymorphisms and AS.

摘要

背景

关于 Toll 样受体 4（TLR4）和 TLR9 基因多态性与强直性脊柱炎（AS）相关性的已有证据存在冲突。本研究旨在通过荟萃分析的方法来探讨 TLR4 和 TLR9 基因多态性是否与 AS 的易感性有关。

方法

检索 PubMed、Web of Science、EMBASE、Cochrane 图书馆、中国知网（CNKI）和万方数据库，获取截至 2020 年 6 月 20 日的相关文献。根据 Newcastle-Ottawa 量表（NOS）评估研究质量。使用比值比（ORs）和 95%置信区间（95% CIs）来判断相关性。

结果

本荟萃分析共纳入 13 项研究，包含 3055 例 AS 病例和 4238 例对照，分析了最广泛报道的四个多态性（TLR4-rs4986790、TLR4-rs4986791、TLR9-rs55704465 和 TLR9-rs187084）。所有纳入的研究均为高质量研究。汇总数据不支持这四个研究的多态性与 AS 易感性之间存在任何显著相关性。