Department of Obstetrics, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (mainland).
Med Sci Monit. 2021 Aug 2;27:e930438. doi: 10.12659/MSM.930438.
BACKGROUND Toll-like receptor 4 (TLR4) plays a pivotal role in the innate immune response and is hyperactivated in preeclampsia (PE). Several researchers have published conflicting evidence for TLR4 rs4986790 and rs4986791 single nucleotide polymorphisms (SNPs) as risk factors for PE. The present meta-analysis was conducted to obtain a more definitive conclusion about the effects of these SNPs on PE susceptibility. MATERIAL AND METHODS To determine the correlation between rs4986790 and rs4986791 polymorphisms in the TLR4 gene and susceptibility to PE, the PubMed, Web of Science, EMBASE, Chinese National Knowledge Infrastructure, and Chinese WANFANG databases were searched for eligible articles. Statistical analysis was performed with STATA software, version 12.0. Pooled odds ratios with corresponding 95% confidence intervals (CIs) were extracted for assessment of correlation strength. RESULTS We identified 5 studies including 578 cases and 631 controls for the rs4986790 SNP and 4 studies including 469 cases and 457 controls for the rs4986791 SNP, mainly from a White population. The pooled analyses showed no statistical relationship between the polymorphisms rs4986790 and rs4986791 and PE susceptibility in 5 genetic models (all P>0.05). Moreover, the allelic and dominant gene models of rs4986790 and the allelic, heterozygous, and dominant gene models of rs4986791 had high heterogeneity. The sensitivity analysis explored potential sources of heterogeneity and confirmed the findings of this meta-analysis. CONCLUSIONS TLR4 rs4986790 and rs4986791 polymorphisms may not be implicated in PE susceptibility, primarily in a White population. More high-quality studies of genetic associations with PE are warranted.
Toll 样受体 4（TLR4）在先天免疫反应中发挥关键作用，并且在先兆子痫（PE）中过度激活。一些研究人员发表了相互矛盾的证据，认为 TLR4 rs4986790 和 rs4986791 单核苷酸多态性（SNP）是 PE 的危险因素。本荟萃分析旨在获得更明确的结论，即这些 SNP 对 PE 易感性的影响。
为了确定 TLR4 基因中 rs4986790 和 rs4986791 多态性与 PE 易感性之间的相关性，检索了 PubMed、Web of Science、EMBASE、中国国家知识基础设施和中国万方数据库中的相关文章。使用 STATA 软件，版本 12.0 进行统计分析。提取合并优势比及其相应的 95%置信区间（CI），用于评估相关性强度。
我们确定了 5 项研究，包括 578 例病例和 631 例对照，用于 rs4986790 SNP，以及 4 项研究，包括 469 例病例和 457 例对照，用于 rs4986791 SNP，主要来自白人人群。荟萃分析显示，在 5 种遗传模型中，多态性 rs4986790 和 rs4986791 与 PE 易感性之间无统计学关系（均 P>0.05）。此外，rs4986790 的等位基因和显性基因模型以及 rs4986791 的等位基因、杂合和显性基因模型存在高度异质性。敏感性分析探讨了异质性的潜在来源，并证实了本荟萃分析的结果。
TLR4 rs4986790 和 rs4986791 多态性可能与 PE 易感性无关，主要在白人人群中。需要更多高质量的研究来探讨与 PE 相关的遗传关联。
