Liu Jia-Xin, An Li-Ping, Jia Yao-Fei, Zhang Guang-Rui, Zhou Jian-Ping, Wu Ding, Zhang Ming-Tao, Yun Xiang-Dong
Department of Orthopaedics, the Second Hospital of Lanzhou University, Key Laboratory of Bone and Joint Diseases in Gansu Province, Lanzhou 730030, Gansu, China.
Zhongguo Gu Shang. 2020 Dec 25;33(12):1175-8. doi: 10.12200/j.issn.1003-0034.2020.12.017.
Titanium alloy has good biological properties and is commonly used in orthopedics, but its bone integrity and antibacterial properties are poor, so surface modification is needed to make up for its shortcomings. Chitosan has good biocompatibility and film forming ability, and can be used as a carrier to introduce the target drug to the surface of titanium alloy, which can effectively improve the biological properties of titanium alloy materials and increase its application range. In this paper, the related research of chitosan surface modified titanium alloy materials in recent years is summarized. The modification methods of chitosan coating, the improvement of osteogenesisand antibacterial properties of titanium alloy materials are discussed in order to provide guidance for the clinical application of coating modification of titanium alloy materials.
钛合金具有良好的生物学性能,常用于骨科领域,但其骨整合性和抗菌性能较差,因此需要进行表面改性以弥补其不足。壳聚糖具有良好的生物相容性和成膜能力,可作为载体将目标药物引入钛合金表面,能有效改善钛合金材料的生物学性能并扩大其应用范围。本文综述了近年来壳聚糖表面改性钛合金材料的相关研究。探讨了壳聚糖涂层的改性方法、钛合金材料成骨性能和抗菌性能的改善,以期为钛合金材料涂层改性的临床应用提供指导。