评价不同分级口腔鳞状细胞癌中 CD117 抗体标记的肥大细胞密度和 CD34 抗体标记的微血管密度。

Evaluation of Mast Cell Density using CD117 antibody and Microvessel Density Using CD34 Antibody in Different Grades of Oral Squamous Cell Carcinoma.

机构信息

Department of Histopathology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan.

Consultant Histopathologist, Armed Forces Institute of Pathology, Rawalpindi, Pakistan.

出版信息

Asian Pac J Cancer Prev. 2020 Dec 1;21(12):3533-3538. doi: 10.31557/APJCP.2020.21.12.3533.

DOI:10.31557/APJCP.2020.21.12.3533

PMID:33369449

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8046326/

Abstract

OBJECTIVE

To compare mast cell and microvessel densities among histologic grades of oral squamous cell carcinoma.

SETTING

Armed Forces Institute of Pathology.

MATERIALS AND METHODS

A total of 60 specimens of OSCC comprising 20 each of well, moderately and poorly differentiated were evaluated. Immunohistochemical analysis was performed to measure MCD and MVD by applying monoclonal CD117 antibody and monoclonal CD34 antibody, on formalin fixed and paraffin embedded sections. ANOVA and Post Hoc Tukey test was employed to assess the densities and to compare the differences between different grades of OSCC. A p-value.

摘要

目的

比较口腔鳞状细胞癌组织学分级中肥大细胞和微血管密度。

地点

武装部队病理研究所。

材料和方法

共评估了 60 例口腔鳞状细胞癌标本，其中包括 20 例分化良好、20 例中度分化和 20 例低分化。采用单克隆 CD117 抗体和单克隆 CD34 抗体，对福尔马林固定和石蜡包埋切片进行免疫组织化学分析，以测量 MCD 和 MVD。采用方差分析和事后 Tukey 检验评估密度，并比较不同分级口腔鳞状细胞癌之间的差异。p 值。