Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China.
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453000, P. R. China.
Org Lett. 2021 Jan 15;23(2):296-299. doi: 10.1021/acs.orglett.0c03773. Epub 2020 Dec 28.
We report herein a direct method to synthesize 4-aryl-3-butenoic acid through a carboxylic-acid-directed oxidative Heck reaction. The various 4-aryl-3-butenoic acids are easily prepared in moderate to good yields. In view of the promising bioactivity of 4-phenyl-3-butenoic acid previously reported, its derivatives reported here may be bioactive.
我们在此报告了一种通过羧酸导向的氧化 Heck 反应直接合成 4-芳基-3-丁烯酸的方法。各种 4-芳基-3-丁烯酸可以以中等至良好的产率轻易地制备。鉴于先前报道的 4-苯基-3-丁烯酸具有有前景的生物活性，此处报道的其衍生物可能具有生物活性。
