黑种草子对超重和肥胖女性的食欲、人体测量和身体成分指标的影响：一项交叉、双盲、安慰剂对照、随机临床试验。
The effect of Nigella sativa on appetite, anthropometric and body composition indices among overweight and obese women: A crossover, double-blind, placebo-controlled, randomized clinical trial.
机构信息
Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Complement Ther Med. 2021 Mar;57:102653. doi: 10.1016/j.ctim.2020.102653. Epub 2020 Dec 25.
OBJECTIVES
Obesity is a global concern which is associated with several complications and disease.
DESIGN
Present study is the first crossover, double-blind, placebo-controlled, randomized clinical trial aimed to evaluate the effect of Nigella Sativa (N. sativa) intervention on anthropometric and body composition parameters as well as dietary intake and appetite in a crossover design.
METHOD
Forty-five healthy women with obesity or overweight were randomized into two groups of intervention and placebo, and the study conducted in two 8-week periods of intervention separated by a 4-week washout period. Anthropometric and body composition indices and dietary intake were measured. Also, appetite sensation was evaluated via a standard visual analog scale (VAS) questionnaire. Pkcross procedure was performed for statistical analysis using STATA. Cohen's d effect size was estimated for all outcomes to determine the magnitude of the effects.
RESULTS
Supplementation with 2000 mg of N. sativa oil found to have a considerable increment in the measures of body mass index (P < 0.001, Cohen's d = 0.5), body weight (P < 0.001, Cohen's d = 0.6) and waist circumference (P = 0.020, Cohen's d = 0.4) with a medium effect size measure, and a significant decrease in body fat mass (P = 0.019, Cohen's d = 0.2), body fat percent (P < 0.001, Cohen's d = 0.2) and visceral fat area (P = 0.011, Cohen's d = 0.2) with a small effect size measure.
CONCLUSION
The overall improvements in anthropometric and body composition parameters and a significant decrease in appetite represents the beneficial effects of N. sativa supplements in the treatment of obesity. More studies with different dosages, a larger number of participants, and longer intervention duration are recommended to illustrate the exact effects of N. sativa as a complementary therapy for obesity.
目的
肥胖是一个全球性的问题，与多种并发症和疾病有关。
设计
本研究是首个交叉、双盲、安慰剂对照、随机临床试验，旨在评估黑种草（N. sativa）干预对人体测量和身体成分参数以及交叉设计中饮食摄入和食欲的影响。
方法
将 45 名肥胖或超重的健康女性随机分为干预组和安慰剂组，研究分为两个 8 周的干预期，中间间隔 4 周洗脱期。测量人体测量和身体成分指数以及饮食摄入量。此外，通过标准视觉模拟量表（VAS）问卷评估食欲感觉。使用 STATA 执行 Pkcross 程序进行统计分析。估计所有结果的 Cohen's d 效应大小，以确定影响的大小。
结果
补充 2000 毫克黑种草油发现，体重指数（P < 0.001，Cohen's d = 0.5）、体重（P < 0.001，Cohen's d = 0.6）和腰围（P = 0.020，Cohen's d = 0.4）有显著增加，具有中等效应大小测量值，身体脂肪量（P = 0.019，Cohen's d = 0.2）、体脂肪百分比（P < 0.001，Cohen's d = 0.2）和内脏脂肪面积（P = 0.011，Cohen's d = 0.2）有显著减少，具有较小的效应大小测量值。
结论
人体测量和身体成分参数的整体改善以及食欲的显著下降表明黑种草补充剂在肥胖治疗中的有益作用。建议进行更多不同剂量、更多参与者和更长干预时间的研究，以说明黑种草作为肥胖辅助治疗的确切效果。
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