Albillos A, Abreu L, Alvarez-Mon M, Gea F, Gonzalo M A, Rossi I, Garrido A, Barrios C, Escartín P
Service of Gastroenterology, Clínica Puerta de Hierro, Universidad Autónoma, Madrid, Spain.
Am J Gastroenterol. 1988 Jan;83(1):37-41.
Thirty-nine subjects have been studied: 14 with hepatic cirrhosis who had not been subjected to surgery, 13 cirrhotic patients in whom portacaval shunt had been performed, and 12 normal controls. In all of them, we performed serum determinations of pepsinogen I, both basal and after pentagastrin stimulation, and of basal gastrin levels, as well as analyses of basal and stimulated gastric acid secretion (basal acid output and maximal acid output). The values for pepsinogen I, basal or post-stimulation, were higher (p less than 0.001) in patients with cirrhosis who had not undergone surgical shunt than in those in the control group. However, there were no statistically significant differences when these two groups were compared with the patients who had been subjected to portacaval shunt. In this last group of patients, seven had levels similar to those of the controls, and six presented higher values. Likewise, the values for gastric acid secretion were similar in the three groups of patients, and the basal gastrin level was lower (p less than 0.001) among patients with liver cirrhosis, whether or not they had undergone surgery, than among the control population. In conclusion, the functional alterations of the gastric mucosa in patients with hepatic cirrhosis are not significantly different from those found in cirrhotic patients with portacaval shunt.
我们对39名受试者进行了研究：14名未接受过手术的肝硬化患者，13名接受过门腔分流术的肝硬化患者，以及12名正常对照者。我们对所有受试者进行了血清胃蛋白酶原I测定（基础值及五肽胃泌素刺激后的值）、基础胃泌素水平测定，以及基础胃酸分泌和刺激胃酸分泌分析（基础酸排出量和最大酸排出量）。未接受手术分流的肝硬化患者的基础或刺激后胃蛋白酶原I值高于对照组（p<0.001）。然而，将这两组与接受过门腔分流术的患者进行比较时，没有统计学上的显著差异。在最后一组患者中，7人的水平与对照组相似，6人的值更高。同样，三组患者的胃酸分泌值相似，肝硬化患者（无论是否接受过手术）的基础胃泌素水平低于对照组（p<0.001）。总之，肝硬化患者胃黏膜的功能改变与接受过门腔分流术的肝硬化患者没有显著差异。
