Li Yuanliang, Fan Guohui, Yu Fuhuan, Tian Chao, Tan Huangying
Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing, China.
Neuroendocrinology. 2021;111(12):1231-1237. doi: 10.1159/000514047. Epub 2020 Dec 28.
Well-differentiated pancreatic neuroendocrine tumors (WDPNETs) are a group of rare and heterogeneous tumors. However, the prognostic factors for recurrence after curative resection still remain controversial. We aim to illustrate the prognostic factors for recurrence of resected WDPNETs.
All relevant articles published through June 2020 were identified via PubMed, Embase, Web of Science, and Cochrane Library. Articles that examined the prognostic factors of WDPNETs were enrolled.
Ten articles were finally included in this study. From 1993 to 2018, 2,863 patients underwent curative resection and 358 patients had recurrence, and the combined recurrence rate was 13%. Furthermore, the pooled data indicated that patients with G2, positive lymph node and surgical resection margin, vascular invasion, and perineural invasion had a decreased disease-free survival for WDPNETs. However, gender, function, and tumor size had no significant relationship with WDPNETs recurrence.
These findings demonstrated that G2, positive lymph node and surgical resection margin, vascular invasion, and perineural invasion could be prognostic factors for recurrence of resected WDPNETs, indicating that patients with these high-risk factors need closer postoperative follow-up and may benefit from adjuvant therapy.
高分化胰腺神经内分泌肿瘤（WDPNETs）是一组罕见且异质性的肿瘤。然而，根治性切除术后复发的预后因素仍存在争议。我们旨在阐明切除的WDPNETs复发的预后因素。
通过PubMed、Embase、科学网和考克兰图书馆检索截至2020年6月发表的所有相关文章。纳入研究WDPNETs预后因素的文章。
本研究最终纳入10篇文章。1993年至2018年，2863例患者接受了根治性切除，358例患者复发，综合复发率为13%。此外，汇总数据表明，G2、淋巴结和手术切缘阳性、血管侵犯和神经周围侵犯的WDPNETs患者无病生存期缩短。然而，性别、功能和肿瘤大小与WDPNETs复发无显著关系。
这些发现表明，G2、淋巴结和手术切缘阳性、血管侵犯和神经周围侵犯可能是切除的WDPNETs复发的预后因素，这表明具有这些高危因素的患者需要更密切的术后随访，可能从辅助治疗中获益。
