Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People's Republic of China.
Pancreas Institute of Nanjing Medical University, Nanjing, 210029, People's Republic of China.
Sci Rep. 2018 May 8;8(1):7271. doi: 10.1038/s41598-018-24072-0.
Pancreatic neuroendocrine neoplasms (pNENs) are a group of clinically rare and heterogeneous diseases of the pancreas. However, the prognostic factors for this disease in patients still remain controversial. The purpose of our study is to evaluate the predictive roles of those prognostic factors for pNENs. All related articles published until Sep 17, 2017 were identified via PubMed, EMBASE, Web of Science, Ovid and the Cochrane Library. Studies that examined the prognostic factors of pNENs were enrolled. 17 articles (2822 patients) were finally included in this study. The pooled data suggested that patients with positive surgical resection margin and lymph node, advanced G stage and TMN stage, organ metastasis, vascular invasion and the necrosis of specimens had a decreased overall survival for pNENs. Similarly, patients with functional tumors might have a poor prognosis. However, age, gender, surgical type and size of tumor could not be regarded as prognostic factors for pNENs. Our analytic data demonstrated that surgical resection margin, G stage, TMN stage, lymph node, metastasis, vascular invasion and the necrosis could be prognostic factors for pNENs. Our study may assist doctors to screen patients with different prognosis more efficiently during follow-up and select appropriate treatment measures.
胰腺神经内分泌肿瘤（pNENs）是一组临床上罕见且具有异质性的胰腺疾病。然而，该疾病患者的预后因素仍存在争议。我们的研究旨在评估这些预后因素对 pNENs 的预测作用。通过 PubMed、EMBASE、Web of Science、Ovid 和 Cochrane Library 检索截至 2017 年 9 月 17 日发表的所有相关文章。纳入了研究 pNENs 预后因素的研究。最终共有 17 篇文章（2822 例患者）纳入本研究。汇总数据表明，pNENs 患者的手术切缘阳性、淋巴结阳性、G 分期和 TMN 分期较晚、器官转移、血管侵犯和标本坏死与总体生存率降低相关。同样，功能性肿瘤患者可能预后不良。然而，年龄、性别、手术类型和肿瘤大小不能作为 pNENs 的预后因素。我们的分析数据表明，手术切缘、G 分期、TMN 分期、淋巴结、转移、血管侵犯和坏死可能是 pNENs 的预后因素。我们的研究可以帮助医生在随访期间更有效地筛选具有不同预后的患者，并选择合适的治疗措施。
