Ziemer D C, Dunlap D B
Department of Medicine, Veterans Administration Medical Center, Augusta, Georgia.
Am J Med Sci. 1988 Jan;295(1):49-51. doi: 10.1097/00000441-198801000-00010.
A patient with longstanding acromegaly complicated by sleep apnea was treated with bromocriptine prior to surgery. In addition to a significant reduction of the plasma growth hormone concentration and measurable decrease in acral overgrowth, a dramatic improvement of the sleep apnea was observed. After three months of therapy, the amount of sleep time occupied by apneic episodes fell from 48 to 12%. The response indicates: (a) that the sequelae sleep apnea in acromegaly can be improved even when ablative therapy of the pituitary is impossible and (b) bromocriptine may prevent perioperative complications caused by clinically significant airway obstruction in patients with acromegaly.
一名患有长期肢端肥大症并伴有睡眠呼吸暂停的患者在手术前接受了溴隐亭治疗。除了血浆生长激素浓度显著降低以及可测量的肢端过度生长减少外，还观察到睡眠呼吸暂停有显著改善。经过三个月的治疗，呼吸暂停发作所占据的睡眠时间从48%降至12%。这一反应表明：(a) 即使无法对垂体进行切除治疗，肢端肥大症中的睡眠呼吸暂停后遗症也可以得到改善；(b) 溴隐亭可能预防肢端肥大症患者因临床上显著的气道阻塞引起的围手术期并发症。
