对抗阿尔茨海默病的潜在表观遗传学靶点。
Potential Epigenetic Targets for Combating Alzheimer's Disease.
机构信息
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Raebareli, India.
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Raebareli,, India.
出版信息
Mini Rev Med Chem. 2021;21(12):1527-1540. doi: 10.2174/1389557521999201228191427.
Memory remains an obligatory regime of the human brain, and impaired memory causes serious obstacles in our everyday life. Alzheimer's disease (AD) is one such neurodegenerative disease which mostly affects the elderly population, above the age of 60; marked by cognitive impairment of memory. Besides the known targets of AD against the several etiologies known to date, the zone of epigenetics has recently evolved as an ingenious field in AD. Epigenetic modifications do not affect DNA sequence but only long-term gene expression. Considering the complex multifactorial nature of AD, we herein discuss the various epigenetic targets which might give rise to potential therapeutic approaches. We reviewed the possible epigenetic targets for AD-like HDAC, Sirtuins, glial cells, miRNA and epigenetic modifications like DNA methylation. A deeper insight into these target areas can surely evolve AD diagnosis and therapeutics.
记忆仍然是人类大脑的强制性机制，而记忆受损会在我们的日常生活中造成严重障碍。阿尔茨海默病（AD）就是这样一种神经退行性疾病，主要影响 60 岁以上的老年人；其特征是记忆认知障碍。除了针对目前已知的几种病因的已知 AD 靶点外，最近，表观遗传学领域已成为 AD 的一个巧妙领域。表观遗传修饰不会影响 DNA 序列，而只会影响长期基因表达。考虑到 AD 的复杂多因素性质，我们在此讨论了可能产生潜在治疗方法的各种表观遗传靶标。我们综述了 AD 样 HDAC、Sirtuins、神经胶质细胞、miRNA 和表观遗传修饰（如 DNA 甲基化）的可能表观遗传靶标。对这些目标区域的更深入了解肯定可以促进 AD 的诊断和治疗。
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