Suppr超能文献

microRNAs 在神经病理学中信号通路的表观遗传调控中的作用。

The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies.

机构信息

Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia.

Scientific and Educational Resource Center "Innovative Technologies of Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis", RUDN University, 117198 Moscow, Russia.

出版信息

Int J Mol Sci. 2023 Aug 17;24(16):12899. doi: 10.3390/ijms241612899.

Abstract

In recent times, there has been a significant increase in researchers' interest in the functions of microRNAs and the role of these molecules in the pathogenesis of many multifactorial diseases. This is related to the diagnostic and prognostic potential of microRNA expression levels as well as the prospects of using it in personalized targeted therapy. This review of the literature analyzes existing scientific data on the involvement of microRNAs in the molecular and cellular mechanisms underlying the development of pathologies such as Alzheimer's disease, cerebral ischemia and reperfusion injury, and dysfunction of the blood-brain barrier.

摘要

近年来,研究人员对 microRNAs 的功能及其在许多多因素疾病发病机制中的作用产生了浓厚的兴趣。这与 microRNA 表达水平的诊断和预后潜力以及在个性化靶向治疗中应用的前景有关。本文对文献进行了回顾,分析了 microRNAs 参与阿尔茨海默病、脑缺血再灌注损伤和血脑屏障功能障碍等疾病的分子和细胞机制的现有科学数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3273/10454825/e4c2e7368006/ijms-24-12899-g001.jpg

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验