Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
Scientific and Educational Resource Center "Innovative Technologies of Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis", RUDN University, 117198 Moscow, Russia.
Int J Mol Sci. 2023 Aug 17;24(16):12899. doi: 10.3390/ijms241612899.
In recent times, there has been a significant increase in researchers' interest in the functions of microRNAs and the role of these molecules in the pathogenesis of many multifactorial diseases. This is related to the diagnostic and prognostic potential of microRNA expression levels as well as the prospects of using it in personalized targeted therapy. This review of the literature analyzes existing scientific data on the involvement of microRNAs in the molecular and cellular mechanisms underlying the development of pathologies such as Alzheimer's disease, cerebral ischemia and reperfusion injury, and dysfunction of the blood-brain barrier.
近年来,研究人员对 microRNAs 的功能及其在许多多因素疾病发病机制中的作用产生了浓厚的兴趣。这与 microRNA 表达水平的诊断和预后潜力以及在个性化靶向治疗中应用的前景有关。本文对文献进行了回顾,分析了 microRNAs 参与阿尔茨海默病、脑缺血再灌注损伤和血脑屏障功能障碍等疾病的分子和细胞机制的现有科学数据。