Department of Preventive Medicine and Public Health. School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
IdiPaz (Instituto de Investigación Sanitaria Hospital Universitario La Paz), Madrid, Spain.
Br J Nutr. 2021 Nov 14;126(9):1347-1354. doi: 10.1017/S0007114520005218. Epub 2020 Dec 29.
It is unknown if time-restricted feeding confers a protective effect on the physical function of older adults. The aim of this study was to assess prolonged nightly fasting in association with performance-based lower-extremity function (LEF) in a large population of community-dwelling older adults. A cross-sectional study was carried out among 1226 individuals ≥64 years from the Seniors-ENRICA-II (Study on Nutrition and Cardiovascular Risk in Spain) cohort. Habitual diet was assessed through a validated diet history. Fasting time was classified into the following categories: ≤9, 10-11 and ≥12 h/d (prolonged nightly fasting). Performance-based LEF was assessed with the Short Physical Performance Battery (SPPB). After adjusting for potential confounders, a longer fasting period was associated with a higher likelihood of impaired LEF (OR for the second and third categories v. ≤ 9 h/d fasting: 2·27 (95 % CI 1·56, 3·33) and 2·70 (95 % CI 1·80, 4·04), respectively; Ptrend < 0·001). Fasting time showed a significant association with the SPPB subtests balance impairment (OR for highest v. shortest fasting time: 2.48; 95 % CI 1·51, 4·08; Ptrend = 0·001) and difficulty to rise from a chair (OR 1·47; 95 % CI 1·05, 2·06; Ptrend = 0·01). The risk associated with ≥12 h fasting among those with the lowest levels of physical activity was three times higher than among those with ≤9 h fasting with the same low level of physical activity. Prolonged nightly fasting was associated with a higher likelihood of impaired LEF, balance impairment, and difficulty to rise from a chair in older adults, especially among those with low levels of physical activity.
限时进食是否对老年人的身体功能有保护作用尚不清楚。本研究旨在评估在大量社区居住的老年人中，长时间夜间禁食与基于表现的下肢功能（LEF）的关系。一项横断面研究在 Seniors-ENRICA-II（西班牙营养与心血管风险研究）队列中进行，共纳入 1226 名年龄≥64 岁的个体。通过验证过的饮食史评估习惯性饮食。禁食时间分为以下几类：≤9 小时、10-11 小时和≥12 小时/天（长时间夜间禁食）。基于表现的下肢功能通过短体适能表现测试（SPPB）进行评估。在调整了潜在混杂因素后，较长的禁食时间与 LEF 受损的可能性增加相关（第二和第三类别与≤9 小时禁食相比的比值比：2.27（95%CI 1.56，3.33）和 2.70（95%CI 1.80，4.04）；P趋势<0.001）。禁食时间与 SPPB 子测试平衡障碍（最高与最短禁食时间相比的比值比：2.48；95%CI 1.51，4.08；P趋势=0.001）和从椅子上站起来的困难（比值比 1.47；95%CI 1.05，2.06；P趋势=0.01）显著相关。在身体活动水平最低的人群中，与≥12 小时禁食相关的风险是与同样低水平身体活动的≤9 小时禁食相比的三倍。在老年人中，尤其是在身体活动水平较低的人群中，长时间夜间禁食与 LEF 受损、平衡障碍和从椅子上站起来困难的可能性增加相关。
