限时进食可改善 2 型糖尿病风险男性的葡萄糖耐量：一项随机交叉试验。

Time-Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial.

机构信息

Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.

NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, South Australia, Australia.

出版信息

Obesity (Silver Spring). 2019 May;27(5):724-732. doi: 10.1002/oby.22449. Epub 2019 Apr 19.

DOI:10.1002/oby.22449

PMID:31002478

Abstract

OBJECTIVE

This study aimed to assess the effects of 9-hour time-restricted feeding (TRF), early (TRFe) or delayed (TRFd), on glucose tolerance in men at risk for type 2 diabetes.

METHODS

Fifteen men (age 55 ± 3 years, BMI 33.9 ± 0.8 kg/m ) wore a continuous glucose monitor for 7 days of baseline assessment and during two 7-day TRF conditions. Participants were randomized to TRFe (8 am to 5 pm) or TRFd (12 pm to 9 pm), separated by a 2-week washout phase. Glucose, insulin, triglycerides, nonesterified fatty acids, and gastrointestinal hormone incremental areas under the curve were calculated following a standard meal on days 0 and 7 at 8 am (TRFe) or 12 pm (TRFd).

RESULTS

TRF improved glucose tolerance as assessed by a reduction in glucose incremental area under the curve (P = 0.001) and fasting triglycerides (P = 0.003) on day 7 versus day 0. However, there were no mealtime by TRF interactions in any of the variables examined. There was also no effect of TRF on fasting and postprandial insulin, nonesterified fatty acids, or gastrointestinal hormones. Mean fasting glucose by continuous glucose monitor was lower in TRFe (P = 0.02) but not TRFd (P = 0.17) versus baseline, but there was no difference between TRF conditions.

CONCLUSIONS

While only TRFe lowered mean fasting glucose, TRF improved glycemic responses to a test meal in men at risk for type 2 diabetes regardless of the clock time that TRF was initiated.

摘要

目的

本研究旨在评估 9 小时限时进食（TRF）、早期（TRFe）或延迟（TRFd）对 2 型糖尿病高危男性的葡萄糖耐量的影响。

方法

15 名男性（年龄 55 ± 3 岁，BMI 33.9 ± 0.8 kg/m ）佩戴连续血糖监测仪进行 7 天的基线评估和 2 种 7 天 TRF 条件下的监测。参与者随机分为 TRFe（8 点至 5 点）或 TRFd（12 点至 9 点），中间间隔 2 周洗脱期。在第 0 天和第 7 天的 8 点（TRFe）或 12 点（TRFd）时，给予标准餐，计算葡萄糖、胰岛素、甘油三酯、非酯化脂肪酸和胃肠激素的曲线下增量面积。

结果

与第 0 天相比，TRF 在第 7 天降低了葡萄糖增量曲线下面积（P = 0.001）和空腹甘油三酯（P = 0.003），从而改善了葡萄糖耐量。然而，在检查的任何变量中，都没有进餐时间与 TRF 的相互作用。TRF 也没有对空腹和餐后胰岛素、非酯化脂肪酸或胃肠激素产生影响。连续血糖监测仪测量的平均空腹血糖在 TRFe 时较低（P = 0.02），但在 TRFd 时则没有差异（P = 0.17），但与基线相比，TRF 条件之间没有差异。