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伴有全层巩膜融解和环形进展的坏死性真菌性巩膜炎:一种新型清创方法

Necrotising fungal scleritis with full-thickness scleral melt and circumferential progression: a novel debridement approach.

作者信息

Karkhur Samendra, Soni Deepak, Sharma Bhavana

机构信息

Department of Ophthalmology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India

Department of Ophthalmology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.

出版信息

BMJ Case Rep. 2020 Dec 28;13(12):e237586. doi: 10.1136/bcr-2020-237586.

Abstract

A 44-year-old Asian Indian woman presented with a history of pain and redness in the left eye for 3 weeks. Scleral congestion with a nodular swelling was present inferotemporally. Raised C reactive protein and positive antinuclear and perinuclear antineutrophil cytoplasmic antibodies suggested autoimmune scleritis. The patient was therefore managed with corticosteroids. Nevertheless, the development of severe pain associated with a scleral abscess led to a revised diagnosis of infectious scleritis. Corticosteroids therapy was halted and urgent debridement was performed. Microbiology confirmed fungal scleritis due to Multiple full-thickness circumferential debridements with antifungal therapy resulted in satisfactory anatomical and visual outcomes. This case presented a unique challenge, since laboratory results were misleading, and corticosteroids resulted in a fulminant clinical course. Therefore, aggressive circumferential debridement was performed to achieve the elimination of a rare fungal aetiology of scleritis, which has not been reported previously to cause human infection.

摘要

一名44岁的亚洲印度裔女性因左眼疼痛和发红3周前来就诊。颞下象限存在巩膜充血并伴有结节状肿胀。C反应蛋白升高以及抗核抗体和抗中性粒细胞胞浆周缘抗体呈阳性提示自身免疫性巩膜炎。因此,该患者接受了皮质类固醇治疗。然而,与巩膜脓肿相关的剧痛的出现导致了感染性巩膜炎的修正诊断。停止了皮质类固醇治疗并进行了紧急清创术。微生物学检查证实为真菌性巩膜炎,病因是……多次全层环形清创术联合抗真菌治疗取得了满意的解剖学和视觉效果。该病例带来了独特的挑战,因为实验室结果具有误导性,且皮质类固醇导致了病情的暴发性发展。因此,进行了积极的环形清创术以消除一种罕见的真菌性巩膜炎病因,此前尚未有该病因导致人类感染的报道。

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