Annamneedi Venkata Prakash, Park Jun Woo, Lee Geum Seon, Kang Tae Jin
Convergence Research Center, Department of Pharmacy and Institute of Chronic Disease, Sahmyook University, Seoul 01795, Republic of Korea.
Department of Counseling and Psychology, Sahmyook University, Seoul 01795, Republic of Korea.
Biomol Ther (Seoul). 2021 Jan 1;29(1):31-40. doi: 10.4062/biomolther.2020.215.
All living beings on earth have an important mechanism of 24-h periodicity, which controls their physiology, metabolism, and behavior. In humans, 24-h periodicity is regulated by the superchiasmatic nucleus (SCN) through external and environmental cues. Peripheral organs demonstrate circadian rhythms and circadian clock functions, and these are also observed in cultured cell lines. Every cell contains a CLOCK: BMAL1 loop for the generation of circadian rhythms. In this review, we focused on cell autonomous circadian rhythms in immune cells, the inflammatory diseases caused by disruption of circadian rhythms in hormones, and the role of clock genes in inflammatory diseases.
地球上所有生物都有一个重要的24小时周期性机制，该机制控制着它们的生理、新陈代谢和行为。在人类中，24小时周期性由视交叉上核（SCN）通过外部和环境线索进行调节。外周器官表现出昼夜节律和生物钟功能，在培养的细胞系中也观察到这些现象。每个细胞都包含一个用于产生昼夜节律的CLOCK:BMAL1环路。在本综述中，我们重点关注免疫细胞中的细胞自主昼夜节律、激素昼夜节律紊乱引起的炎症性疾病以及生物钟基因在炎症性疾病中的作用。
