Center of Digital Dentistry, Peking University School and Hospital of Stomatology, Beijing, China.
Research Center of Engineering and Technology for Digital Dentistry, Ministry of Health, Beijing, China.
J Appl Biomater Funct Mater. 2020 Jan-Dec;18:2280800019836400. doi: 10.1177/2280800019836400.
Magnesium alloys have been potential biodegradable implants in the areas of bone, cardiovascular system, gastrointestinal tract, and so on. The purpose of this study is to evaluate Mg-2Zn alloy degradation as a potential suture material. The study included Sprague-Dawley (SD) rats in vivo. In 24 male SD rats, tests in the leg muscle were conducted using traditional surgical incision and insertion of magnesium alloys of different designs into the tissue. The material degradation topography, elemental composition, and strength of the pins were analyzed. This paper explores magnesium pins with different cross-sectional shapes and diameters to establish a suitable pin diameter and shape for use as an oral stapler, which must have a good balance of degradation rate and strength. The results showed there were good bending strengths over different degradation periods in groups with diameters of 0.8 mm and 0.5 mm, and no significantly different bending strength between the groups of triangle and round cross-section shapes with same diameter of 0.3 mm, although the degradation rate still needs to be improved.
镁合金已成为骨骼、心血管系统、胃肠道等领域中具有潜力的可生物降解植入物。本研究旨在评估 Mg-2Zn 合金作为潜在缝合材料的降解性能。该研究纳入了 Sprague-Dawley（SD）大鼠进行体内实验。在 24 只雄性 SD 大鼠中，通过传统的手术切口和将不同设计的镁合金插入组织中，对腿部肌肉进行了测试。分析了材料降解形貌、元素组成和销钉的强度。本文探索了具有不同横截面形状和直径的镁钉，以确定一种适合用作口腔吻合器的合适钉直径和形状，该吻合器必须具有良好的降解率和强度之间的平衡。结果表明，在直径为 0.8mm 和 0.5mm 的组中，在不同的降解期内均具有良好的弯曲强度，并且直径为 0.3mm 的三角形和圆形横截面形状的组之间的弯曲强度没有显著差异，尽管降解率仍有待提高。
