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绿茶及其主要成分(表没食子儿茶素-3-没食子酸酯)在缓解疼痛中的潜在作用:一项机制综述。

The Potential Role of Green Tea and its Main Constituent (Epigallocatechin -3-Gallate) in Pain Relief: A Mechanistic Review.

作者信息

Negah Sajad Sahab, Ghazavi Hamed, Vafaee Farzaneh, Rashidi Roghayeh, Aminian Ahmad Reza, Forouzanfar Fatemeh

机构信息

Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Curr Drug Discov Technol. 2021;18(6):e130921189586. doi: 10.2174/1570163817666201229121033.

DOI:10.2174/1570163817666201229121033
PMID:33372878
Abstract

Medicinal plants and dietary supplements may provide an effective and safe treatment for pain relief. Green tea is one of the most common beverages with many several pharmacological activities. The results of various studies have indicated that green tea possesses antinociceptive effects. Many of the protective effects of green tea in terms of pain relief are attributed to its antioxidant and anti-inflammatory properties. Epigallocatechin -3-gallate (EGCG), as one of the major phytochemical components in green tea, is effective in the management of pain through suppression of inflammation and oxidative stress. We have reviewed the effects of green tea on pain and also discussed mechanisms involved in pain relief. This review suggests that green tea can be a safe and often effective treatment for pain.

摘要

药用植物和膳食补充剂可能为缓解疼痛提供一种有效且安全的治疗方法。绿茶是最常见的饮品之一,具有多种药理活性。各项研究结果表明绿茶具有抗伤害感受作用。绿茶在缓解疼痛方面的许多保护作用归因于其抗氧化和抗炎特性。表没食子儿茶素 -3- 没食子酸酯(EGCG)作为绿茶中的主要植物化学成分之一,通过抑制炎症和氧化应激对疼痛管理有效。我们综述了绿茶对疼痛的影响,并讨论了缓解疼痛所涉及的机制。本综述表明绿茶可以是一种安全且通常有效的疼痛治疗方法。

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1
The Potential Role of Green Tea and its Main Constituent (Epigallocatechin -3-Gallate) in Pain Relief: A Mechanistic Review.绿茶及其主要成分(表没食子儿茶素-3-没食子酸酯)在缓解疼痛中的潜在作用:一项机制综述。
Curr Drug Discov Technol. 2021;18(6):e130921189586. doi: 10.2174/1570163817666201229121033.
2
Green tea extract and (-)-epigallocatechin-3-gallate, the major tea catechin, exert oxidant but lack antioxidant activities.绿茶提取物和主要的茶儿茶素(-)-表没食子儿茶素-3-没食子酸酯具有氧化作用,但缺乏抗氧化活性。
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Epigallocatechin-3-gallate (EGCG): chemical and biomedical perspectives.表没食子儿茶素-3-没食子酸酯(EGCG):化学与生物医学视角
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Anti-inflammatory Action of Green Tea.绿茶的抗炎作用。
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Preparation and antioxidant activity of green tea extract enriched in epigallocatechin (EGC) and epigallocatechin gallate (EGCG).富含表没食子儿茶素(EGC)和表没食子儿茶素没食子酸酯(EGCG)的绿茶提取物的制备及其抗氧化活性
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Green tea: nature's defense against malignancies.绿茶:大自然对抗恶性肿瘤的防御手段。
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Dietary pretreatment with green tea polyphenol, (-)-epigallocatechin-3-gallate reduces the bioavailability and hepatotoxicity of subsequent oral bolus doses of (-)-epigallocatechin-3-gallate.用绿茶多酚(-)-表没食子儿茶素-3-没食子酸酯进行饮食预处理可降低随后口服大剂量(-)-表没食子儿茶素-3-没食子酸酯的生物利用度和肝毒性。
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Quantification of ascorbyl adducts of epigallocatechin gallate and gallocatechin gallate in bottled tea beverages.定量分析瓶装茶饮料中表没食子儿茶素没食子酸酯和没食子儿茶素没食子酸酯的抗坏血酸加合物。
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