运动训练对 2 型肌强直性营养不良患者功能能力和身体成分的影响。
Effect of exercise training on functional capacity and body composition in myotonic dystrophy type 2 patients.
机构信息
Sports Performance Laboratory, School of Physical Education & Sport Science, National and Kapodistrian University of Athens, Athens, Greece.
1st Department of Neurology, Eginition Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
出版信息
Muscle Nerve. 2021 Apr;63(4):477-483. doi: 10.1002/mus.27156. Epub 2021 Jan 15.
BACKGROUND
Myotonic dystrophy type 2 (DM2) is a neuromuscular disorder characterized by myotonia and muscle weakness, with no medical treatment to prevent a decline in decline. It is unknown whether exercise training is effective in DM2. The aim of this study was to investigate the effect of exercise training on functional capacity and body composition in these patients.
METHODS
Body composition and functional capacity were evaluated at the beginning (T1) and end (T2) of a 12 wk control period, and again after 16 wk of exercise training (T3) in 10 patients.
RESULTS
No changes were recorded after the control period. Handgrip strength, 5× sit to stand, timed up and go, 6 min walk distance, lean body mass (LBM), and bone mineral density (BMD) increased while arterial pressure decreased after training.
CONCLUSIONS
These results suggest that supervised exercise training improves functional capacity, LBM, and BMD in ambulatory DM2 patients.
背景
肌强直性营养不良 2 型（DM2）是一种以肌强直和肌肉无力为特征的神经肌肉疾病，目前尚无预防疾病进展的治疗方法。运动训练是否对 DM2 有效尚不清楚。本研究旨在探讨运动训练对这些患者的功能能力和身体成分的影响。
方法
在 12 周的对照期（T1）和结束时（T2）以及 16 周的运动训练后（T3）评估身体成分和功能能力，共评估了 10 名患者。
结果
在对照期后没有记录到变化。握力、5 次坐站、计时起立行走、6 分钟步行距离、瘦体重（LBM）和骨密度（BMD）增加，而训练后动脉压降低。
结论
这些结果表明，监督下的运动训练可改善 DM2 患者的运动功能能力、LBM 和 BMD。
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