Suppr超能文献

主观运动性抱怨和新发缓慢步态。

Subjective Motoric Complaints and New Onset Slow Gait.

机构信息

Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.

Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.

出版信息

J Gerontol A Biol Sci Med Sci. 2021 Sep 13;76(10):e245-e252. doi: 10.1093/gerona/glaa321.

Abstract

BACKGROUND

While reports of mobility problems are common with aging, their relationship to new onset of slow gait is unknown. Our objective was to examine the validity of subjective motoric complaints for predicting the incidence of slow gait.

METHODS

Ambulatory community-residing participants (mean age 76.6, 55% women) with gait speeds in the normal range enrolled in an aging cohort. Five subjective motoric complaints were assessed. Incident slow gait (walking speed 1 SD below age and sex means) was the primary outcome.

RESULTS

Of the 548 participants at baseline, 90 had prevalent slow gait and 253 participants (73.7%) reported one or more subjective motoric complaints. Subjective motoric complaints were more common in women than men (1.78 vs 1.23). Over a median follow-up of 3.34 years, 68 participants developed new onset slow gait. All 5 questions predicted incident slow gait (adjusted hazard ratios varying from 2.26 to 4.44). More subjective motoric complaints were associated with increased risk of developing incident slow gait (hazard ratio per complaint 1.81). Predictive validity of subjective motoric complaints for incident slow gait was unchanged when using alternate outcome definitions, accounting for diagnostic misclassification, recall bias, or adjusting for multiple confounders.

CONCLUSIONS

Subjective motoric complaints are a harbinger of mobility disability, and can help improve clinical risk assessments and identify high-risk individuals for interventions to prevent onset of slow gait.

摘要

背景

随着年龄的增长,行动不便的报告很常见,但它们与新出现的缓慢步态的关系尚不清楚。我们的目的是研究主观运动性抱怨对预测缓慢步态发生率的有效性。

方法

在一个老龄化队列中,招募了有正常行走速度的社区居住的、有活动能力的参与者(平均年龄 76.6 岁,55%为女性)。评估了 5 种主观运动性抱怨。新发缓慢步态(行走速度比年龄和性别平均值低 1 个标准差)是主要结局。

结果

在基线时的 548 名参与者中,有 90 名患有常见的缓慢步态,有 253 名参与者(73.7%)报告了一种或多种主观运动性抱怨。女性比男性更常见主观运动性抱怨(1.78 比 1.23)。在中位数为 3.34 年的随访中,有 68 名参与者新发缓慢步态。所有 5 个问题都预测了新发缓慢步态(调整后的危险比从 2.26 到 4.44 不等)。更多的主观运动性抱怨与新发缓慢步态的风险增加相关(每抱怨一个的风险比为 1.81)。当使用替代结局定义、考虑诊断错误分类、回忆偏倚或调整多个混杂因素时,主观运动性抱怨对新发缓慢步态的预测有效性不变。

结论

主观运动性抱怨是行动不便的先兆,可以帮助改善临床风险评估,并确定需要干预以预防缓慢步态发生的高风险个体。

相似文献

1
Subjective Motoric Complaints and New Onset Slow Gait.
J Gerontol A Biol Sci Med Sci. 2021 Sep 13;76(10):e245-e252. doi: 10.1093/gerona/glaa321.
3
The association between pain and prevalent and incident motoric cognitive risk syndrome in older adults.
Arch Gerontol Geriatr. 2020 Mar-Apr;87:103991. doi: 10.1016/j.archger.2019.103991. Epub 2019 Nov 30.
5
Non-memory subjective cognitive concerns predict incident motoric cognitive risk syndrome.
Eur J Neurol. 2020 Jul;27(7):1146-1154. doi: 10.1111/ene.14271. Epub 2020 May 19.
7
Association between motoric cognitive risk syndrome and frailty among older Chinese adults.
BMC Geriatr. 2020 Mar 19;20(1):110. doi: 10.1186/s12877-020-01511-0.
8
Motoric cognitive risk syndrome and the risk of dementia.
J Gerontol A Biol Sci Med Sci. 2013 Apr;68(4):412-8. doi: 10.1093/gerona/gls191. Epub 2012 Sep 17.
9
Motoric Cognitive Risk Syndrome Subtypes and Cognitive Profiles.
J Gerontol A Biol Sci Med Sci. 2016 Mar;71(3):378-84. doi: 10.1093/gerona/glv092. Epub 2015 Aug 6.
10
Frailty and Risk of Incident Motoric Cognitive Risk Syndrome.
J Alzheimers Dis. 2019;71(s1):S85-S93. doi: 10.3233/JAD-190517.

引用本文的文献

3
Trajectories of frailty in aging: Prospective cohort study.
PLoS One. 2021 Jul 12;16(7):e0253976. doi: 10.1371/journal.pone.0253976. eCollection 2021.

本文引用的文献

1
Home-Based Gait Speed Assessment: Normative Data and Racial/Ethnic Correlates Among Older Adults.
J Am Med Dir Assoc. 2019 Oct;20(10):1224-1229. doi: 10.1016/j.jamda.2019.06.002. Epub 2019 Aug 5.
2
Gait Dysfunction in Motoric Cognitive Risk Syndrome.
J Alzheimers Dis. 2019;71(s1):S95-S103. doi: 10.3233/JAD-181227.
3
Prevalence of Disabilities and Health Care Access by Disability Status and Type Among Adults - United States, 2016.
MMWR Morb Mortal Wkly Rep. 2018 Aug 17;67(32):882-887. doi: 10.15585/mmwr.mm6732a3.
4
Subjective cognitive decline: The first clinical manifestation of Alzheimer's disease?
Dement Neuropsychol. 2016 Jul-Sep;10(3):170-177. doi: 10.1590/S1980-5764-2016DN1003002.
5
A Comparison of Self-report Indices of Major Mobility Disability to Failure on the 400-m Walk Test: The LIFE Study.
J Gerontol A Biol Sci Med Sci. 2018 Mar 14;73(4):513-518. doi: 10.1093/gerona/glx153.
6
Subjective Cognitive Decline in Preclinical Alzheimer's Disease.
Annu Rev Clin Psychol. 2017 May 8;13:369-396. doi: 10.1146/annurev-clinpsy-032816-045136.
7
8
Brain activation in high-functioning older adults and falls: Prospective cohort study.
Neurology. 2017 Jan 10;88(2):191-197. doi: 10.1212/WNL.0000000000003421. Epub 2016 Dec 7.
9
Age-Related Change in Mobility: Perspectives From Life Course Epidemiology and Geroscience.
J Gerontol A Biol Sci Med Sci. 2016 Sep;71(9):1184-94. doi: 10.1093/gerona/glw043. Epub 2016 Mar 14.
10
Modifiable Risk Factors for New-Onset Slow Gait in Older Adults.
J Am Med Dir Assoc. 2016 May 1;17(5):421-5. doi: 10.1016/j.jamda.2016.01.017. Epub 2016 Feb 26.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验