Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
J Surg Oncol. 2021 Mar;123(4):1126-1133. doi: 10.1002/jso.26358. Epub 2020 Dec 29.
All-polyethylene (AP) tibial components have demonstrated equivalent or improved long-term survivorship and reduced cost compared with metal-backed (MB) components in primary total knee arthroplasty; however, there is a lack of data comparing these outcomes in the setting of an oncologic endoprosthetic reconstruction.
A total of 115 (88 AP:27 MB) patients undergoing cemented distal femur endoprosthetic reconstruction following oncologic resection were reviewed. Mean age was 40 years and 51% were females. Cumulative incidences of all-cause revision, tibial component revision, reoperation, and infection were calculated utilizing a competing risk analysis with death as the competitor. Mean follow-up was 14 years.
The 10-year cumulative incidence of all-cause revision was 19.9% in the AP group and 16.3% in the MB group (hazard ratio [HR] = 0.93, p = 0.88). The cumulative incidence of tibial component revision was significantly lower in AP compared with MB at 10 years (1.1% vs. 12.5%, HR = 0.18, p = 0.03). There was no difference in infection-free survival when comparing the two groups (p = 0.72).
Reconstruction utilizing an MB or AP tibia component resulted in equivalent overall outcome; however, the tibial component in the AP group was less likely to be revised. AP tibial component should be considered for all primary oncologic reconstructions in the distal femur. LEVEL OF EVIDENCE: Level III Therapeutic.
在初次全膝关节置换中,全聚乙烯(AP)胫骨组件在长期生存率和降低成本方面与金属背衬(MB)组件相当或更优;然而,在肿瘤假体重建的背景下,缺乏比较这些结果的数据。
回顾了 115 例(88 例 AP:27 例 MB)接受肿瘤切除后骨水泥固定远端股骨假体重建的患者。平均年龄为 40 岁,51%为女性。采用竞争风险分析计算全因翻修、胫骨组件翻修、再次手术和感染的累积发生率,以死亡为竞争风险。平均随访时间为 14 年。
AP 组 10 年全因翻修的累积发生率为 19.9%,MB 组为 16.3%(风险比[HR] = 0.93,p = 0.88)。AP 组胫骨组件翻修的累积发生率明显低于 MB 组,10 年时为 1.1%比 12.5%(HR = 0.18,p = 0.03)。两组在无感染生存方面无差异(p = 0.72)。
使用 MB 或 AP 胫骨组件进行重建的结果相当;然而,AP 组的胫骨组件更不容易翻修。AP 胫骨组件应考虑用于远端股骨的所有初次肿瘤重建。
治疗性 3 级。