Department of Orthopedic Surgery, McGill University Health Centre, Montreal, Canada.
Department of Orthopedic Surgery, Mayo Clinic, Phoenix AZ.
J Arthroplasty. 2021 Aug;36(8):2913-2920. doi: 10.1016/j.arth.2021.03.033. Epub 2021 Mar 18.
Both cemented and cementless stemmed endoprosthetic implants have been used to reconstruct large skeletal defects after tumor resection with similar outcomes. In this study, we examined the oncologic, clinical, and functional outcomes in patients undergoing distal femur replacement using the French paradox technique.
A total of 125 patients who underwent distal femur replacement between 1990 and 2019 using the line-to-line cementation technique were reviewed. Implant failure was recorded as per Henderson's classification. Functional outcomes were analyzed using the Musculoskeletal Tumor Society and Toronto Extremity Salvage Score scoring systems. The mean follow-up was 84 (1-350) months.
Aseptic loosening of the femoral stem was recorded in one patient at 21-years of follow-up. Twenty of 125 patients required bushing exchange for polyethylene wear, all after 10 years. Six tibial bearing component fractures were recorded in four patients while one femoral stem component Morse taper fractured. Two all-polyethylene cemented tibial implants were revised for polyethylene granuloma. Deep surgical site infection occurred in 13 patients, while six patients experienced local recurrence. Kaplan-Meier estimates for implant survival for all-cause revision were 85% at 1 year and 70% at 5 years. These estimates for femur or tibia loosening as an end point were 96% at 10 years and 90% at 15 years. The mean Musculoskeletal Tumor Society and Toronto Extremity Salvage Score scores at the last follow-up were 76% and 74%, respectively. Thirty-five patients died of disease progression.
The line-to-line cementation technique, used with all-polyethylene tibial implants, demonstrates low incidence of aseptic loosening at medium and long-term follow-ups.
III.
在肿瘤切除后,为重建大的骨骼缺损,使用骨水泥型和非骨水泥型髓内假体植入物的效果相似。本研究采用法国悖论技术对接受股骨远端置换的患者进行了肿瘤学、临床和功能预后的评估。
回顾了 1990 年至 2019 年期间采用线对线骨水泥固定技术行股骨远端置换的 125 例患者。根据 Henderson 分类记录假体失败情况。采用肌肉骨骼肿瘤学会(Musculoskeletal Tumor Society,MSTS)和多伦多下肢挽救评分(Toronto Extremity Salvage Score,TESS)评分系统分析功能结果。平均随访时间为 84(1-350)个月。
1 例患者在随访 21 年时出现股骨柄无菌性松动。20/125 例患者因聚乙烯磨损需要更换衬垫,均在 10 年后。4 例患者中有 6 例胫骨负重组件骨折,1 例股骨柄组件 Morse 锥断裂。2 例全聚乙烯骨水泥固定胫骨植入物因聚乙烯肉芽肿而翻修。13 例患者发生深部手术部位感染,6 例患者发生局部复发。所有原因翻修的假体生存率估计,Kaplan-Meier 为 1 年时 85%,5 年时 70%。作为终点的股骨或胫骨松动的估计生存率,10 年时为 96%,15 年时为 90%。末次随访时 MSTS 和 TESS 评分的平均分别为 76%和 74%。35 例患者因疾病进展而死亡。
对线对线骨水泥固定技术,与全聚乙烯胫骨植入物一起使用,在中、长期随访中显示出低的无菌性松动发生率。
III 级