Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India.
Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India.
Int J Biol Macromol. 2021 Feb 15;170:326-335. doi: 10.1016/j.ijbiomac.2020.12.173. Epub 2020 Dec 26.
Bone remodeling is a complex event that maintains bone homeostasis. The epigenetic mechanism of the regulation of bone remodeling has been a major research focus over the past decades. Histone acetylation is an influential post-translational modification in chromatin architecture. Acetylation affects chromatin structure by offering binding signals for reader proteins that harbor acetyl-lysine recognition domains. This review summarizes recent data of histone acetylation in bone remodeling. The crux of this review is the functional role of histone acetyltransferases, the key promoters of histone acetylation. The functional regulation of acetylation via noncoding RNAs in bone remodeling is also discussed. Understanding the principles governing histone acetylation in bone remodeling would lead to the development of better epigenetic therapies for bone diseases.
骨重建是维持骨稳态的一个复杂事件。在过去几十年中，骨重建调控的表观遗传机制一直是主要的研究焦点。组蛋白乙酰化是染色质结构中一种有影响力的翻译后修饰。乙酰化通过为含有乙酰化赖氨酸识别结构域的阅读器蛋白提供结合信号来影响染色质结构。本文综述了骨重建中组蛋白乙酰化的最新数据。本文的核心是组蛋白乙酰转移酶的功能作用，组蛋白乙酰转移酶是组蛋白乙酰化的关键促进剂。还讨论了非编码 RNA 在骨重建中通过乙酰化的功能调控。了解骨重建中组蛋白乙酰化的调控原则将为骨疾病的表观遗传治疗的发展提供指导。
