Craft J B, Goldberg N H, Lim M, Landsberger E, Mazel P, Abramson F P, Stolte A L, Braswell M E, Farina J P
Department of Anesthesiology, George Washington University Medical Center, Washington, DC 20037.
Anesthesiology. 1988 Jan;68(1):68-72. doi: 10.1097/00000542-198801000-00011.
Using the chronic maternal-fetal sheep preparation, nine pregnant ewes were studied to determine the effects of intravenous dantrolene sodium on maternal and fetal physiology, with particular reference to its placental passage, and its effects on uterine blood flow and uterine tone. Two doses of dantrolene sodium were studied: 1.2 mg/kg and 2.4 mg/kg. After 2.4 mg/kg, maternal cardiac output increased 29% (P less than 0.05) after 1 min and returned to normal after 30 min. Maternal mean arterial pressure increased 13% after 1 min and remained significantly elevated (P less than 0.01) for 3 h. No significant changes (P greater than 0.05) were observed in maternal heart rate, uterine artery blood flow, or central venous pressure. Maternal arterial pH declined from 7.42 to 7.39 (P less than 0.01) after 1 min and returned to baseline values after 10 min. Fetal heart rate decreased 24% (P less than 0.01) after 3 min and returned to normal after 10 min; the mean fetal arterial pressure remained unchanged (P greater than 0.05). Fetal arterial pH declined from 7.29 to 7.27 (P less than 0.05) after 1 min and remained significantly decreased for 120 min. Similar changes of lesser magnitude and shorter duration were seen following the 1.2 mg/kg dose. Maternal levels of dantrolene were less than 3 micrograms/ml. Although an equilibrium between maternal and fetal plasma dantrolene concentrations was apparent at 5 min, the fetal levels of dantrolene were approximately 10% of the mother's. The results indicate that the administration of intravenous dantrolene at 1.2 mg/kg or 2.4 mg/kg has no clinically significant adverse effect on mother or fetus in the sheep model.
利用慢性母胎绵羊模型，对9只怀孕母羊进行研究，以确定静脉注射丹曲林钠对母羊和胎儿生理的影响，尤其关注其胎盘转运情况，以及对子宫血流和子宫张力的影响。研究了两种剂量的丹曲林钠：1.2mg/kg和2.4mg/kg。注射2.4mg/kg后，1分钟内母羊心输出量增加29%（P<0.05），30分钟后恢复正常。1分钟后母羊平均动脉压升高13%，并在3小时内持续显著升高（P<0.01）。母羊心率、子宫动脉血流或中心静脉压未观察到显著变化（P>0.05）。1分钟后母羊动脉pH值从7.42降至7.39（P<0.01），10分钟后恢复至基线值。3分钟后胎儿心率下降24%（P<0.01），10分钟后恢复正常；胎儿平均动脉压保持不变（P>0.05）。1分钟后胎儿动脉pH值从7.29降至7.27（P<0.05），并在120分钟内持续显著下降。注射1.2mg/kg剂量后观察到类似但程度较轻、持续时间较短的变化。母羊体内丹曲林水平低于3微克/毫升。尽管5分钟时母胎血浆丹曲林浓度达到平衡，但胎儿体内丹曲林水平约为母体的10%。结果表明，在绵羊模型中，静脉注射1.2mg/kg或2.4mg/kg的丹曲林对母羊或胎儿没有临床显著的不良影响。
