Barone J A, Raia J J, Huang Y C
College of Pharmacy, Rutgers State University, Piscataway, New Jersey 08855-0789.
Ann Emerg Med. 1988 Jan;17(1):34-7. doi: 10.1016/s0196-0644(88)80500-6.
The effects of multiple-dose activated charcoal administration on the absorption of orally administered salicylate were evaluated in a simulated overdose model. Thirteen adult volunteers were each given 24 81-mg aspirin tablets during a control phase, and during three randomized treatment periods the volunteers received 50 g activated charcoal for one, two, or three doses (separated by four hours). The control phase and treatment periods were separated by a one-week interval. Urine was collected for 48 hours to determine percent total salicylate excretion. Ten subjects completed all four phases of the study. Mean +/- SD percent recovery of salicylate from urine was: control, 91.0 +/- 6.12; one-dose charcoal, 68.3 +/- 12.46; two-dose charcoal, 65.9 +/- 13.48; and three-dose charcoal, 49.2 +/- 12.48. Each charcoal treatment significantly lowered the absorption of aspirin as compared with the control (P less than .01). There was no significant difference between one-dose and two-dose charcoal regimens. There was a statistically significant decrease in salicylate absorption with the three-dose charcoal regimen as compared to one-dose and two-dose regimens (P less than .01). We conclude that activated charcoal is effective in inhibiting absorption of orally administered salicylate, in a small-dose aspirin ingestion model, with a three-dose multiple charcoal regimen being superior to either single-dose or two-dose regimens.
在一个模拟过量用药模型中评估了多次给予活性炭对口服水杨酸盐吸收的影响。在对照阶段，13名成年志愿者每人服用24片81毫克的阿司匹林片剂，在三个随机治疗阶段，志愿者分别接受1剂、2剂或3剂（间隔4小时）50克活性炭。对照阶段和治疗阶段间隔一周。收集48小时尿液以测定水杨酸盐排泄总量的百分比。10名受试者完成了研究的所有四个阶段。水杨酸盐从尿液中的平均回收率（%）±标准差为：对照，91.0±6.12；1剂活性炭，68.3±12.46；2剂活性炭，65.9±13.48；3剂活性炭，49.2±12.48。与对照相比，每种活性炭治疗均显著降低了阿司匹林的吸收（P<0.01）。1剂和2剂活性炭方案之间无显著差异。与1剂和2剂方案相比，3剂活性炭方案使水杨酸盐吸收有统计学显著下降（P<0.01）。我们得出结论，在小剂量阿司匹林摄入模型中，活性炭可有效抑制口服水杨酸盐的吸收，三剂多次活性炭方案优于单剂或两剂方案。
