Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Via Luigi De Crecchio, 80138 Naples, Italy.
Department of Pharmacy, University of Naples "Federico II", Via Domenico Montesano 49, 80131 Naples, Italy.
Int J Mol Sci. 2020 Dec 24;22(1):103. doi: 10.3390/ijms22010103.
In order to study novel therapeutic approaches taking advantage of natural compounds showing anticancer and anti-proliferative effects, we focused our interest on S-adenosyl-l-methionine, a naturally occurring sulfur-containing nucleoside synthesized from adenosine triphosphate and methionine by methionine adenosyltransferase, and its potential in overcoming drug resistance in colon cancer cells devoid of p53.
In the present study, we demonstrated that S-adenosyl-l-methionine overcomes uL3-mediated drug resistance in p53 deleted colon cancer cells. In particular, we demonstrated that S-adenosyl-l-methionine causes cell cycle arrest at the S phase; inhibits autophagy; augments reactive oxygen species; and induces apoptosis in these cancer cells.
Results reported in this paper led us to propose S-adenosyl-l-methionine as a potential promising agent for cancer therapy by examining p53 and uL3 profiles in tumors to yield a better clinical outcomes.
为了研究利用具有抗癌和抗增殖作用的天然化合物的新治疗方法，我们将兴趣集中在 S-腺苷甲硫氨酸上，S-腺苷甲硫氨酸是一种由三磷酸腺苷和蛋氨酸通过蛋氨酸腺苷转移酶合成的天然含硫核苷，及其在克服缺乏 p53 的结肠癌细胞耐药性方面的潜力。
在本研究中，我们证明 S-腺苷甲硫氨酸可克服 p53 缺失的结肠癌细胞中 uL3 介导的耐药性。具体而言，我们证明 S-腺苷甲硫氨酸可使细胞周期在 S 期停滞；抑制自噬；增加活性氧；并诱导这些癌细胞凋亡。
本文报道的结果促使我们提出 S-腺苷甲硫氨酸作为癌症治疗的一种有前途的潜在药物，通过检查肿瘤中的 p53 和 uL3 谱来获得更好的临床结果。
