Reichert Cadiele Oliana, Levy Debora, Bydlowski Sergio P
Lipids, Oxidation, and Cell Biology Group, Laboratory of Immunology (LIM19), Heart Institute (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-900, Brazil.
Instituto Nacional de Ciencia e Tecnologia em Medicina Regenerativa (INCT-Regenera), CNPq, Rio de Janeiro 21941-902, Brazil.
Antioxidants (Basel). 2020 Dec 24;10(1):11. doi: 10.3390/antiox10010011.
The human body has biological redox systems capable of preventing or mitigating the damage caused by increased oxidative stress throughout life. One of them are the paraoxonase (PON) enzymes. The PONs genetic cluster is made up of three members (PON1, PON2, PON3) that share a structural homology, located adjacent to chromosome seven. The most studied enzyme is PON1, which is associated with high density lipoprotein (HDL), having paraoxonase, arylesterase and lactonase activities. Due to these characteristics, the enzyme PON1 has been associated with the development of neurodegenerative diseases. Here we update the knowledge about the association of PON enzymes and their polymorphisms and the development of multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD).
人体拥有生物氧化还原系统，能够在一生中预防或减轻因氧化应激增加而造成的损害。其中之一是对氧磷酶（PON）酶。PON基因簇由三个成员（PON1、PON2、PON3）组成，它们具有结构同源性，位于7号染色体附近。研究最多的酶是PON1，它与高密度脂蛋白（HDL）相关，具有对氧磷酶、芳基酯酶和内酯酶活性。由于这些特性，PON1酶已与神经退行性疾病的发展相关联。在此，我们更新了关于PON酶及其多态性与多发性硬化症（MS）、肌萎缩侧索硬化症（ALS）、阿尔茨海默病（AD）和帕金森病（PD）之间关联的知识。
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