Proaño Belén, Benlloch María, Sancho-Castillo Sandra, Privado Jesús, Bargues-Navarro Guillermo, Sanchis-Sanchis Claudia Emmanuela, Martínez Bolós Palmira, Carriquí-Suárez Ana Belén, Cubero-Plazas Laura, Platero Armero Jose Luis, Escriva Dolores, Ceron Jose Joaquín, Tvarijonaviciute Asta, de la Rubia Ortí Jose Enrique
Doctoral School, Catholic University of Valencia, 46001 Valencia, Spain.
Department of Basic Biomedical Sciences, Catholic University of Valencia, 46001 Valencia, Spain.
Antioxidants (Basel). 2024 Aug 22;13(8):1021. doi: 10.3390/antiox13081021.
: Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration, with oxidative stress playing a key role. Paraoxonase 1 (PON1) is an antioxidant enzyme that may influence ALS progression. This study aimed to establish a predictive model for the influence of PON1 activity on functionality in ALS patients and explore its relationship with nutrition. In this observational cross-sectional study, 70 ALS patients underwent assessments of PON1 activity, lipid profile, functional capacity, respiratory function, and heart rate variability. A structural equation model was developed to determine the relationships between variables. Nutritional intake was analyzed in 65 patients. The predictive model showed that PON1 activity and LDL levels positively influenced functionality, both directly and indirectly through respiratory capacity. Heart rate variability moderately predicted functionality independently. HDL levels were not significantly associated with functionality. Weak to moderate correlations were found between PON1 activity and intake of certain nutrients, with positive associations for monounsaturated fats and vitamin D, and negative associations for carbohydrates, proteins, and some micronutrients. PON1 activity appears to play an important role in ALS patient functionality, both directly and through effects on respiratory capacity. However, its relationship with nutritional intake was not strongly evident in this sample population.
肌萎缩侧索硬化症（ALS）的特征是进行性运动神经元退化，氧化应激在其中起关键作用。对氧磷酶1（PON1）是一种抗氧化酶，可能会影响ALS的进展。本研究旨在建立一个预测模型，以评估PON1活性对ALS患者功能的影响，并探讨其与营养的关系。在这项观察性横断面研究中，70例ALS患者接受了PON1活性、血脂谱、功能能力、呼吸功能和心率变异性的评估。建立了一个结构方程模型来确定变量之间的关系。对65例患者的营养摄入情况进行了分析。预测模型显示，PON1活性和低密度脂蛋白水平直接或通过呼吸能力间接对功能产生积极影响。心率变异性可独立中度预测功能。高密度脂蛋白水平与功能无显著相关性。PON1活性与某些营养素的摄入量之间存在弱至中度的相关性，其中单不饱和脂肪和维生素D呈正相关，碳水化合物、蛋白质和一些微量营养素呈负相关。PON1活性似乎在ALS患者的功能中起着重要作用，无论是直接作用还是通过对呼吸能力的影响。然而，在这个样本群体中，其与营养摄入的关系并不十分明显。
