Jimenez-Ruiz Aila, Prado-Gotor Rafael, Fernández-Bolaños José G, González-Benjumea Alejandro, Carnerero José María
Department of Physical Chemistry, University of Seville. c/Profesor García González 1, 41012 Seville, Spain.
Department of Organic Chemistry, University of Seville. c/Profesor García González 1, 41012 Seville, Spain.
Materials (Basel). 2020 Dec 24;14(1):50. doi: 10.3390/ma14010050.
Stable oleuropein-coated gold nanoparticles in aqueous media were synthesized for the first time. Oleuropein (OLE) concentration in the reaction medium was found to greatly influence the outcome and stability of the resulting nanocolloid, with a marked decrease in particle size being found for the more concentrated oleuropein solutions. The protection mechanisms involved in the stabilized nanosystems were analyzed. Oleuropein self-assembled structures were found to be formed at a concentration threshold of [OLE] > 5 × 10 M, and observed through the use of CryoSEM imaging. Those structures were responsible for both the increased stability and the decrease in size observed at the more concentrated solutions.
首次在水性介质中合成了稳定的橄榄苦苷包覆金纳米颗粒。发现反应介质中橄榄苦苷（OLE）的浓度对所得纳米胶体的结果和稳定性有很大影响，对于浓度较高的橄榄苦苷溶液，粒径明显减小。分析了稳定化纳米系统中涉及的保护机制。发现橄榄苦苷自组装结构在[OLE] > 5 × 10 M的浓度阈值下形成，并通过低温扫描电子显微镜成像观察到。这些结构导致了在浓度较高的溶液中观察到的稳定性增加和尺寸减小。
