Department of Obstetrics and Gynaecology, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
Division of Infection Control, Environment and Health, Norwegian Institute of Public Health, 0213 Oslo, Norway.
Nutrients. 2020 Dec 23;13(1):23. doi: 10.3390/nu13010023.
Selenium is an essential trace element involved in the body's redox reactions. Low selenium intake during pregnancy has been associated with low birth weight and an increased risk of children being born small for gestational age (SGA). Based on data from the Norwegian Mother, Father and Child Cohort Study (MoBa) and the Medical Birth Registry of Norway (MBRN), we studied the association of maternal selenium intake from diet and supplements during the first half of pregnancy ( = 71,728 women) and selenium status in mid-pregnancy ( = 2628 women) with birth weight and SGA status, according to population-based, ultrasound-based and customized growth standards. An increase of one standard deviation of maternal dietary selenium intake was associated with increased birth weight z-scores ( = 0.027, 95% CI: 0.007, 0.041) and lower SGA risk (OR = 0.91, 95% CI 0.86, 0.97) after adjusting for confounders. Maternal organic and inorganic selenium intake from supplements as well as whole blood selenium concentration were not associated with birth weight or SGA. Our results suggest that a maternal diet rich in selenium during pregnancy may be beneficial for foetal growth. However, the effect estimates were small and further studies are needed to elucidate the potential impact of selenium on foetal growth.
硒是一种参与体内氧化还原反应的必需微量元素。怀孕期间硒摄入不足与低出生体重和儿童出生时小于胎龄儿（SGA）的风险增加有关。基于挪威母婴队列研究（MoBa）和挪威医学出生登记处（MBRN）的数据，我们研究了母亲在妊娠前半段饮食和补充剂中的硒摄入（= 71728 名女性）和妊娠中期硒状况（= 2628 名女性）与出生体重和 SGA 状态之间的关系，根据基于人群、基于超声和定制的生长标准。调整混杂因素后，母亲饮食中硒摄入量增加一个标准差与出生体重 z 分数增加（= 0.027，95%CI：0.007，0.041）和 SGA 风险降低（OR=0.91，95%CI0.86，0.97）相关。补充剂中的有机硒和无机硒以及全血硒浓度与出生体重或 SGA 无关。我们的研究结果表明，怀孕期间富含硒的饮食可能有益于胎儿生长。然而，效应估计值较小，需要进一步的研究来阐明硒对胎儿生长的潜在影响。
