Stehlík Ladislav, Di Tommaso Morena, Del Signore Francesca, Paninárová Michaela, Terragni Rossella, Magni Tommaso, Pontonutti Luisa, Carloni Andrea, Alberti Monica, De Magistris Angela V, Vignoli Massimo
Small Animal Clinic, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1946/1, 61242 Brno, Czech Republic.
Faculty of Veterinary Medicine, University of Teramo, Piano D'Accio, 64100 Teramo, Italy.
Animals (Basel). 2020 Dec 23;11(1):11. doi: 10.3390/ani11010011.
The liver has a unique vascular supply, and triple-phase contrast-enhanced computed tomography examinations are being performed in order to characterize liver lesions. This study aimed to look for any associations between the attenuation values of liver lesions and their histological classification. The inclusion criteria for this retrospective study were focal or multifocal liver lesions and histological diagnosis. All of the dogs underwent pre-contrast and triple-phase postcontrast computed tomography (CT) examinations with identical timings of the postcontrast series. Thirty-one dogs were included in the study, and various benign and malignant pathologies were identified. The results did not identify any significant differences between the benign and malignant liver lesions, nor between the individual histological diagnoses. Inflammatory lesions were significantly different compared to the normal liver parenchyma, and significant hypoattenuation was found in the portal and delayed venous phases. Hemangiosarcomas were significantly hypoattenuating to the normal liver parenchyma in the pre-contrast and arterial phases, and also to all of the benign lesions in the arterial phase. The other pathologies showed variable attenuation patterns in the different postcontrast phases, and differentiation was not possible. On the basis of this study, triple-phase contrast-enhanced computed tomography cannot differentiate between benign and malignant liver lesions, and biopsy and further histological analysis are necessary.
肝脏具有独特的血管供应，目前正在进行三相对比增强计算机断层扫描检查，以对肝脏病变进行特征描述。本研究旨在寻找肝脏病变的衰减值与其组织学分类之间的任何关联。这项回顾性研究的纳入标准为局灶性或多灶性肝脏病变以及组织学诊断。所有犬只均接受了造影前和造影后三相计算机断层扫描（CT）检查，造影后系列检查的时间相同。31只犬被纳入研究，发现了各种良性和恶性病变。结果未发现良性和恶性肝脏病变之间以及各个组织学诊断之间存在任何显著差异。与正常肝实质相比，炎性病变有显著差异，在门静脉期和延迟静脉期发现明显的低密度影。在造影前和动脉期，血管肉瘤相对于正常肝实质以及在动脉期相对于所有良性病变均有显著的低密度影。其他病变在不同的造影后阶段显示出不同的衰减模式，无法进行鉴别。基于本研究，三相对比增强计算机断层扫描无法区分良性和恶性肝脏病变，活检和进一步的组织学分析是必要的。
