Clinic for Diagnostic Imaging, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Vetimage Diagnostik GmbH, Oberentfelden, Switzerland.
PLoS One. 2022 Jan 7;17(1):e0260436. doi: 10.1371/journal.pone.0260436. eCollection 2022.
Many pathologies can occur in the periportal space and manifest as fluid accumulation, visible in Computed tomography (CT) images as a circumferential region of low attenuation around the intrahepatic portal vessels, called periportal halo (PPH). This finding is associated with different types of hepatic and extra-hepatic disease in humans and remains a non-specific sign of unknown significance in veterinary literature. The aim of this study was to investigate the prevalence of PPH in a population of patients undergoing CT examination and to assess the presence of lesions related to hepatic and extra-hepatic disease in presence of PPH. CT studies including the cranial abdomen of dogs and cats performed over a 5-year period were retrospectively reviewed. The prevalence of PPH was 15% in dogs and 1% in cats. 143 animals were included and the halo was classified as mild, moderate and severe, respectively in 51%, 34% and 15% of animals. The halo distribution was generalized in 79 cases, localized along the second generation of portal branches in 63, and along the first generation only in one. Hepatic disease was present in 58/143 and extra-hepatic disease in 110/143 of the cases. Main cause of hepatic (36%) and extra-hepatic disease (68%) was neoplasia. Associations between halo grades and neoplasia revealed to be not statistically significant (p = 0.057). In 7% of animals the CT examination was otherwise unremarkable. PPH is a non-specific finding, occurring in presence of a variety of diseases in the examined patient population.
许多病理学改变可发生于门脉周围间隙，并表现为液体聚集，在 CT 图像上可见肝内门脉血管周围的环状低衰减区，称为门脉周围晕（PPH）。这种表现与人类的各种肝内和肝外疾病相关，在兽医文献中仍然是一种意义不明的非特异性征象。本研究旨在调查行 CT 检查的患者群体中 PPH 的发生率，并评估 PPH 患者中与肝内和肝外疾病相关的病变的存在情况。回顾性分析了在 5 年期间进行的包括颅腹部 CT 研究的犬猫病例。PPH 在犬中的发生率为 15%，在猫中为 1%。共纳入 143 例动物，根据 PPH 的严重程度，将其分为轻度、中度和重度，分别占 51%、34%和 15%。79 例动物的晕呈弥漫性分布，63 例动物的晕呈 2 代门脉分支周围局限性分布，1 例动物的晕仅局限于 1 代门脉分支周围。143 例动物中有 58 例存在肝内疾病，110 例存在肝外疾病。肝内疾病（36%）和肝外疾病（68%）的主要病因是肿瘤。晕的严重程度与肿瘤之间的相关性无统计学意义（p = 0.057）。7%的动物的 CT 检查无明显异常。PPH 是一种非特异性表现，在检查患者群体中存在多种疾病。
