Kutara Kenji, Seki Mamiko, Ishigaki Kumiko, Teshima Kenji, Ishikawa Chieko, Kagawa Yumiko, Edamura Kazuya, Nakayama Tomohiro, Asano Kazushi
Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan.
North Lab, 35-8-2 Hondoori Shiraishi, Sapporo, Hokkaido 003-0027, Japan.
J Vet Med Sci. 2017 Nov 17;79(11):1870-1877. doi: 10.1292/jvms.17-0253. Epub 2017 Oct 7.
We investigated the utility of triple-phase helical computed tomography (CT) in differentiating between benign and malignant splenic masses in dogs. Forty-two dogs with primary splenic masses underwent triple-phase helical CT scanning (before administration of contrast, and in the arterial phase, portal venous phase, and delayed phase) prior to splenectomy. Tissue specimens were sent for pathological diagnosis; these included hematomas (n=14), nodular hyperplasias (n=12), hemangiosarcomas (n=11), and undifferentiated sarcomas (n=5). The CT findings were compared with the histological findings. Nodular hyperplasia significantly displayed a homogeneous normal enhancement pattern in all phases. Hemangiosarcoma displayed 2 significant contrast-enhancement patterns, including a homogeneous pattern of poor enhancement in all phases, and a heterogeneous remarkable enhancement pattern in the arterial and portal venous phases. Hematoma and undifferentiated sarcoma displayed a heterogeneous normal enhancement pattern in all phases. The contrast-enhanced volumetric ratios of hematoma tended to be greater than those of undifferentiated sarcoma. Our study demonstrated that the characteristic findings on triple-phase helical CT could be useful for the preoperative differentiation of hematoma, nodular hyperplasia, hemangiosarcoma, and undifferentiated sarcoma in dogs. Triple-phase helical CT may be a useful diagnostic tool in dogs with splenic masses.
我们研究了三相螺旋计算机断层扫描（CT）在鉴别犬脾脏良性和恶性肿块中的应用价值。42只患有原发性脾脏肿块的犬在脾切除术前接受了三相螺旋CT扫描（注射造影剂前、动脉期、门静脉期和延迟期）。组织标本送去做病理诊断；其中包括血肿（n = 14）、结节性增生（n = 12）、血管肉瘤（n = 11）和未分化肉瘤（n = 5）。将CT检查结果与组织学检查结果进行比较。结节性增生在所有阶段均显著呈现均匀的正常强化模式。血管肉瘤呈现出2种显著的对比增强模式，包括所有阶段均匀的低强化模式，以及动脉期和门静脉期不均匀的显著强化模式。血肿和未分化肉瘤在所有阶段均呈现不均匀的正常强化模式。血肿的对比增强体积比往往大于未分化肉瘤。我们的研究表明，三相螺旋CT的特征性表现有助于术前鉴别犬的血肿、结节性增生、血管肉瘤和未分化肉瘤。三相螺旋CT可能是诊断犬脾脏肿块的一种有用的诊断工具。
