Potaś Joanna, Szymańska Emilia, Basa Anna, Hafner Anita, Winnicka Katarzyna
Department of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15-222 Białystok, Poland.
Department of Physical Chemistry, Faculty of Chemistry, University of Białystok, Ciołkowskiego 1K, 15-245 Białystok, Poland.
Materials (Basel). 2020 Dec 27;14(1):86. doi: 10.3390/ma14010086.
Polyelectrolyte complexes based on the electrostatic interactions between the polymers mixed are of increasing importance, therefore, the aim of this study was to develop hydrogels composed of anionic tragacanth gum and cationic chitosan with or without the addition of anionic xanthan gum as carriers for buccal drug delivery. Besides the routine quality tests evaluating the hydrogel's applicability on the buccal mucosa, different methods directed toward the assessment of the interpolymer complexation process (e.g., turbidity or zeta potential analysis, scanning electron microscopy and Fourier-transform infrared spectroscopy) were employed. The addition of xanthan gum resulted in stronger complexation of chitosan that affected the hydrogel's characteristics. The formation of a more viscous PEC hydrogel with improved mucoadhesiveness and mechanical strength points out the potential of such polymer combination in the development of buccal drug dosage forms.
基于混合聚合物之间静电相互作用的聚电解质复合物越来越重要，因此，本研究的目的是开发由阴离子黄芪胶和阳离子壳聚糖组成的水凝胶，添加或不添加阴离子黄原胶作为口腔给药载体。除了评估水凝胶在口腔黏膜上适用性的常规质量测试外，还采用了不同方法来评估聚合物间的络合过程（如浊度或zeta电位分析、扫描电子显微镜和傅里叶变换红外光谱）。添加黄原胶导致壳聚糖更强的络合，这影响了水凝胶的特性。形成具有改善的粘膜粘附性和机械强度的更粘稠的聚电解质复合物水凝胶，指出了这种聚合物组合在口腔药物剂型开发中的潜力。
