IQUIR-CONICET, Suipacha 570, 2000 Rosario, Argentina.
IQUIR-CONICET, Suipacha 570, 2000 Rosario, Argentina; Área Técnica Farmacéutica, Departamento Farmacia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 570, 2000 Rosario, Argentina.
Int J Pharm. 2018 Sep 5;548(1):431-442. doi: 10.1016/j.ijpharm.2018.07.023. Epub 2018 Jul 6.
Numerous films with a dissolved or dispersed active principle within a polymeric matrix have been described in literature. However, the incorporation of solid crystals into the films may influence several relevant properties. Additionally, it has been reported that different polymeric matrices lead to films presenting a different performance. The aim of this work was to evaluate the effect of the combination of chitosan with carrageenan (κ-, λ-, and ι-) as matrices, and of the miconazole nitrate incorporation method, on the films behavior. Mechanical properties, drug release and antifungal activity were evaluated. The state of the drug in the films was analyzed by different techniques. Films showed a homogeneous surface and a thermal protective effect on the drug. The combination of chitosan and λ-carrageenan leads to films with the highest values of tensile and mucoadhesive strength. Films with solubilized drug displayed slightly higher elongation at break, tensile and mucoadhesive strength and faster drug release than those with suspended miconazole nitrate. However, no differences were found regarding the antifungal activity of the different formulations including time-to-kill curves.
文献中描述了许多将溶解或分散的活性成分包含在聚合物基质中的薄膜。然而，将固体晶体掺入薄膜中可能会影响若干相关性能。此外，据报道，不同的聚合物基质会导致具有不同性能的薄膜。本工作旨在评估壳聚糖与角叉菜胶（κ-、λ-和 ι-）作为基质的组合，以及硝酸咪康唑掺入方法对薄膜性能的影响。对机械性能、药物释放和抗真菌活性进行了评估。通过不同的技术分析了药物在薄膜中的状态。薄膜表面均匀，对药物具有热保护作用。壳聚糖和 λ-角叉菜胶的组合导致具有最高拉伸和黏膜粘着强度的薄膜。与悬浮的硝酸咪康唑相比，溶解药物的薄膜具有稍高的断裂伸长率、拉伸强度和黏膜粘着强度以及更快的药物释放。然而，不同制剂（包括杀菌时间曲线）的抗真菌活性没有差异。
