Division of Hematology, Department of Human Pathology in Adulthood and Childhood "Gaetano Barresi", University of Messina, 98125 Messina, Italy.
Clinical Physiology Institute, National Research Council of Italy (IFC-CNR), 56124 Pisa, Italy.
Int J Mol Sci. 2020 Dec 25;22(1):146. doi: 10.3390/ijms22010146.
is a widely present plant, and extracts of its leaves, flowers, and aerial elements have been employed for many years as therapeutic cures for depression, skin wounds, and respiratory and inflammatory disorders. also displays an ample variety of other biological actions, such as hypotensive, analgesic, anti-infective, anti-oxidant, and spasmolytic abilities. However, recent investigations highlighted that this species could be advantageous for the cure of other pathological situations, such as trigeminal neuralgia, as well as in the treatment of cancer. This review focuses on the in vitro and in vivo antitumor effects of St. John's Wort ( its derivatives, and other species in hematologic malignancies. induces apoptosis in both myeloid and lymphoid cells. Other targets include matrix metalloproteinase-2, vascular endothelial growth factor, and matrix metalloproteinase-9, which are mediators of cell migration and angiogenesis. also downregulates the expression of proteins that are involved in the resistance of leukemia cells to chemotherapeutic agents. Finally, and its derivatives appear to have photodynamic effects and are candidates for applications in tumor photodynamic therapy. Although the in vitro studies appear promising, controlled in vivo studies are necessary before we can hypothesize the introduction of and its derivatives into clinical practice for the treatment of hematologic malignancies.
贯叶连翘是一种广泛存在的植物，其叶子、花朵和地上部分的提取物多年来一直被用作治疗抑郁症、皮肤创伤、呼吸道和炎症性疾病的药物。贯叶连翘还具有多种其他生物学作用，如降压、镇痛、抗感染、抗氧化和抗痉挛作用。然而，最近的研究表明，该物种可能有助于治疗其他病理情况，如三叉神经痛，以及癌症的治疗。本文综述了贯叶连翘（及其衍生物）和其他贯叶连翘属植物在血液系统恶性肿瘤中的体外和体内抗肿瘤作用。贯叶连翘诱导髓系和淋巴系细胞凋亡。其他靶点包括基质金属蛋白酶-2、血管内皮生长因子和基质金属蛋白酶-9，它们是细胞迁移和血管生成的介质。贯叶连翘还下调参与白血病细胞对化疗药物耐药的蛋白表达。最后，贯叶连翘和其衍生物似乎具有光动力作用，是肿瘤光动力治疗应用的候选药物。虽然体外研究显示出良好的前景，但在我们假设将贯叶连翘及其衍生物引入血液系统恶性肿瘤的临床治疗之前，还需要进行对照的体内研究。
