Cancemi Gabriella, Cicero Nicola, Allegra Alessandro, Gangemi Sebastiano
Division of Hematology, Department of Human Pathology in Adulthood and Childhood "Gaetano Barresi", University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
Antioxidants (Basel). 2023 Aug 26;12(9):1674. doi: 10.3390/antiox12091674.
Lymphomas are a heterogeneous group of pathologies that result from clonal proliferation of lymphocytes. They are classified into Hodgkin lymphoma and non-Hodgkin lymphoma; the latter develops as a result of B, T, or NK cells undergoing malignant transformation. It is believed that diet can modulate cellular redox state and that oxidative stress is implicated in lymphomagenesis by acting on several biological mechanisms; in fact, oxidative stress can generate a state of chronic inflammation through the activation of various transcription factors, thereby increasing the production of proinflammatory cytokines and causing overstimulation of B lymphocytes in the production of antibodies and possible alterations in cellular DNA. The purpose of our work is to investigate the results of in vitro and in vivo studies on the possible interaction between lymphomas, oxidative stress, and diet. A variety of dietary regimens and substances introduced with the diet that may have antioxidant and antiproliferative effects were assessed. The possibility of using nutraceuticals as novel anticancer agents is discussed; although the use of natural substances in lymphoma therapy is an interesting field of study, further studies are needed to define the efficacy of different nutraceuticals before introducing them into clinical practice.
淋巴瘤是由淋巴细胞克隆性增殖引起的一组异质性病理疾病。它们分为霍奇金淋巴瘤和非霍奇金淋巴瘤；后者是B细胞、T细胞或NK细胞发生恶性转化的结果。据信，饮食可调节细胞氧化还原状态，并且氧化应激通过作用于多种生物学机制而与淋巴瘤发生有关；事实上，氧化应激可通过激活各种转录因子产生慢性炎症状态，从而增加促炎细胞因子的产生，并导致B淋巴细胞在产生抗体过程中受到过度刺激以及细胞DNA可能发生改变。我们工作的目的是研究关于淋巴瘤、氧化应激和饮食之间可能相互作用的体外和体内研究结果。评估了各种饮食方案以及饮食中引入的可能具有抗氧化和抗增殖作用的物质。讨论了使用营养保健品作为新型抗癌药物的可能性；尽管在淋巴瘤治疗中使用天然物质是一个有趣的研究领域，但在将不同的营养保健品引入临床实践之前，还需要进一步研究来确定其疗效。
