Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
University of the Chinese Academy of Sciences, Beijing, China.
Nat Prod Res. 2022 Jul;36(14):3529-3537. doi: 10.1080/14786419.2020.1867131. Epub 2020 Dec 30.
A new cyclo-heptadepsipeptide xanthostatin B (), together with isobutyryl hexapeptide (), xanthostatin (), TXS-1 () and TXS-2 (), were isolated from the marine sponge derived sp. SCSIO 40064. The structures were elucidated by comprehensive spectroscopic data analyses and comparison with the literatures. The D-Val unit in was assigned by Marfey's method. The absolute configuration of was determined by X-ray crystallographic analysis. Compounds ‒ were evaluated for the inhibitory activities against four pharmaceutical targets and six antibacterial indicator strains. Compound displayed -glucosidase inhibitory activity with IC value of 18.67 ± 1.27 µM.
从海洋海绵来源的 sp. SCSIO 40064 中分离得到了一种新的环庚二肽黄质素 B ()，以及异丁酰六肽 (), 黄质素 (), TXS-1 () 和 TXS-2 ()。通过全面的光谱数据分析和与文献的比较，确定了这些结构。通过 Marfey 法确定了 在 中的 D-Val 单元。通过 X 射线晶体学分析确定了 的绝对构型。对化合物 - 对四个药物靶点和六个抗菌指示菌株的抑制活性进行了评价。化合物 对 -葡萄糖苷酶表现出抑制活性，IC 值为 18.67 ± 1.27 μM。
