Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, People's Republic of China.
Drug Des Devel Ther. 2020 Dec 22;14:5659-5665. doi: 10.2147/DDDT.S285752. eCollection 2020.
To investigate the effectiveness and safety of subconjunctival/perilesional 5-fluorouracil injections on ocular surface squamous neoplasia (OSSN) during a 3-year follow-up period.
We followed up six patients with intraepithelial OSSN (in one eye each) that had regressed after subconjunctival/perilesional 5-fluorouracil injections. Conjunctival fluorescein angiography (FA) and indocyanine green angiography (ICGA), as well as anterior segment optical coherence tomography (AS-OCT), were performed to evaluate the OSSN status 3 years after initiation of treatment.
The mean age of patients (five males, one female) at baseline was 62.3±11.6 years. The mean number of 5-fluorouracil injections was 17.0±8.6, with a mean treatment duration of 13.0±7.4 weeks. At the final visit, both intratumoral and conjunctival feeding vessels had disappeared on ICGA and FA, with no neovascularization-related leakage, in accordance with the results of AS-OCT. The period from complete tumor regression to final visit according to AS-OCT was 32.5±4.2 months, which was longer than that according to ICGA (31.3±3.2 months, p=0.034). The final best-corrected visual acuity was similar to that at baseline (p=0.128). No side effects were observed in any of the eyes.
Subconjunctival/perilesional 5-fluorouracil injections are an effective and safe treatment for OSSN. Future studies with a larger sample size are warranted for confirmation of our findings, as well as investigation into the reasons for residual areas of non-perfusion in the conjunctiva.
在 3 年的随访期间，研究结膜下/病变周围注射 5-氟尿嘧啶对眼表鳞状上皮肿瘤（OSSN）的有效性和安全性。
我们对结膜下/病变周围注射 5-氟尿嘧啶后消退的 6 例上皮内 OSSN（每只眼 1 例）患者进行了随访。在治疗开始后 3 年，通过结膜荧光素血管造影（FA）和吲哚菁绿血管造影（ICGA）以及眼前节光学相干断层扫描（AS-OCT）评估 OSSN 状态。
患者（5 名男性，1 名女性）的平均年龄为 62.3±11.6 岁。平均注射 5-氟尿嘧啶次数为 17.0±8.6 次，平均治疗时间为 13.0±7.4 周。在最后一次就诊时，ICGA 和 FA 均显示肿瘤内和结膜供养血管消失，无新生血管相关渗漏，与 AS-OCT 结果一致。根据 AS-OCT，从肿瘤完全消退到最后一次就诊的时间为 32.5±4.2 个月，长于根据 ICGA 的时间（31.3±3.2 个月，p=0.034）。最终最佳矫正视力与基线时相似（p=0.128）。所有眼睛均未观察到不良反应。
结膜下/病变周围注射 5-氟尿嘧啶是治疗 OSSN 的有效且安全的方法。需要更大样本量的研究来证实我们的发现，并研究结膜未灌注残留区的原因。
