Ophthalmic Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China; Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, USA.
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, USA.
Ocul Surf. 2020 Oct;18(4):926-935. doi: 10.1016/j.jtos.2020.03.009. Epub 2020 Apr 25.
To visualize and quantify vascular networks in individuals with ocular surface squamous neoplasia (OSSN) through optical coherence tomography angiography (OCTA).
Cross-sectional study of OSSN patients. Vascular networks were measured by OCTA in the epithelium and sub-epithelial space in the tumors, adjacent tissue, and in the contralateral eye. Vessel area density (VAD, percent of blood vessels within 2.14 mm), was calculated for each location. Total tumor density (TTD, percent of blood vessels within the entire tumor) was calculated. VAD was assessed separately for corneal and conjunctival locations and compared.
Fifteen patients with OSSN were included. The mean age was 61 ± 12 years and the majority were male (80%). The mean tumor area, volume, depth, and TTD were 28.0 ± 9.0 mm (range, 10.9-39.7), 9.1 ± 4.1 mm (range, 3.4-18.8), 334 ± 125 μm (range, 177-571), and 33.2% ± 11.0% (range, 18.7-58.8), respectively. The VAD was highest within the tumor (28.9% ± 8.7%) followed by the adjacent sub-epithelial tissue and the tissue underneath the conjunctival component of tumor. These densities were higher than the VAD in the tissues of the non-involved eye (all P < 0.05). The VAD within conjunctival component of tumor was significantly higher than those with corneal component (29.8% ± 9.5% vs. 21.1% ± 5.5%, p = 0.006). The VAD under conjunctival tumor was also significantly higher than under corneal component (24.1% ± 7.8% vs. 17.0% ± 6.1%, p = 0.024).
OCTA imaging allowed for visualization and quantification of vessel structure and density within, under, and surrounding OSSN.
通过光相干断层扫描血管造影术（OCTA）可视化和量化患有眼表鳞状细胞肿瘤（OSSN）个体的血管网络。
对 OSSN 患者进行横断面研究。通过 OCTA 在肿瘤的上皮和上皮下空间、相邻组织以及对侧眼中测量血管网络。计算每个位置的血管面积密度（VAD，血管占 2.14mm 内的百分比）。计算整个肿瘤的总肿瘤密度（TTD，血管占整个肿瘤的百分比）。分别评估角膜和结膜位置的 VAD，并进行比较。
纳入 15 名患有 OSSN 的患者。平均年龄为 61±12 岁，大多数为男性（80%）。平均肿瘤面积、体积、深度和 TTD 分别为 28.0±9.0mm（范围，10.9-39.7）、9.1±4.1mm（范围，3.4-18.8）、334±125μm（范围，177-571）和 33.2%±11.0%（范围，18.7-58.8）。VAD 在肿瘤内最高（28.9%±8.7%），其次是相邻的上皮下组织和肿瘤结膜成分下的组织。这些密度均高于未受累眼的组织（均 P<0.05）。肿瘤结膜成分内的 VAD 明显高于角膜成分（29.8%±9.5%比 21.1%±5.5%，p=0.006）。肿瘤下结膜的 VAD 也明显高于角膜下结膜（24.1%±7.8%比 17.0%±6.1%，p=0.024）。
OCTA 成像可用于可视化和量化 OSSN 内、下和周围的血管结构和密度。
