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本文引用的文献

1
Vaccines for measles, mumps, rubella, and varicella in children.儿童麻疹、腮腺炎、风疹和水痘疫苗。
Cochrane Database Syst Rev. 2020 Apr 20;4(4):CD004407. doi: 10.1002/14651858.CD004407.pub4.
2
American Society of Hematology 2019 guidelines for immune thrombocytopenia.美国血液学会 2019 年免疫性血小板减少症治疗指南。
Blood Adv. 2019 Dec 10;3(23):3829-3866. doi: 10.1182/bloodadvances.2019000966.
3
Physician decision making in selection of second-line treatments in immune thrombocytopenia in children.儿童免疫性血小板减少症二线治疗选择中的医生决策。
Am J Hematol. 2018 Jul;93(7):882-888. doi: 10.1002/ajh.25110. Epub 2018 May 6.
4
Immune thrombocytopenic purpura (ITP) associated with vaccinations: a review of reported cases.与疫苗接种相关的免疫性血小板减少性紫癜(ITP):病例报告综述
Immunol Res. 2014 Dec;60(2-3):226-35. doi: 10.1007/s12026-014-8597-x.
5
Vaccine administration and the development of immune thrombocytopenic purpura in children.疫苗接种与儿童免疫性血小板减少性紫癜的发病。
Hum Vaccin Immunother. 2013 May;9(5):1158-62. doi: 10.4161/hv.23601. Epub 2013 Jan 16.
6
ITP in children: pathophysiology and current treatment approaches.儿童免疫性血小板减少症:病理生理学与当前治疗方法
J Pediatr Hematol Oncol. 2013 Jan;35(1):1-13. doi: 10.1097/MPH.0b013e318271f457.
7
The risk of immune thrombocytopenic purpura after vaccination in children and adolescents.儿童和青少年接种疫苗后的免疫性血小板减少性紫癜风险。
Pediatrics. 2012 Feb;129(2):248-55. doi: 10.1542/peds.2011-1111. Epub 2012 Jan 9.
8
Detection of platelet-binding anti-measles and anti-rubella virus IgG antibodies in infants with vaccine-induced thrombocytopenic purpura.检测婴儿血小板结合性抗麻疹和抗风疹病毒 IgG 抗体与疫苗诱导的血小板减少性紫癜。
Vaccine. 2011 Jul 12;29(31):4878-80. doi: 10.1016/j.vaccine.2011.04.036. Epub 2011 May 1.
9
Thrombocytopenic purpura after measles-mumps-rubella vaccination: a systematic review of the literature and guidance for management.麻疹-腮腺炎-风疹疫苗接种后血小板减少性紫癜:文献系统评价及治疗指南。
J Pediatr. 2010 Apr;156(4):623-8. doi: 10.1016/j.jpeds.2009.10.015. Epub 2010 Jan 25.
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POSTRUBELLA THROMBOCYTOPENIC PURPURA.风疹后血小板减少性紫癜
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接种麻疹、腮腺炎、风疹疫苗后出现严重免疫性血小板减少症并快速康复:一例报告及文献综述

Severe Immune Thrombocytopenia Following MMR Vaccination with Rapid Recovery: A Case Report and Review of Literature.

作者信息

Akbik Majd, Naddeh Dima, Ashour Anas A, Ashour Azzam

机构信息

Al-Thumama Health Center, Primary Health Care Corporation, Doha 26555, Qatar.

Muaither Health Center, Primary Health Care Corporation, Doha 26555, Qatar.

出版信息

Int Med Case Rep J. 2020 Dec 15;13:697-699. doi: 10.2147/IMCRJ.S286335. eCollection 2020.

DOI:10.2147/IMCRJ.S286335
PMID:33376414
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7755875/
Abstract

Immune thrombocytopenia (ITP) is an autoimmune disease that occurs following viral illnesses and may also infrequently occur after measles, mumps, and rubella (MMR) vaccination. ITP typically presents with the sudden appearance of a petechial rash, bruising, and/or bleeding in an otherwise healthy-appearing child. However, ITP following MMR vaccine does not commonly cause severely depleted platelets. We report a case of ITP after MMR vaccination in a 13-month-old baby boy, who presented with petechial rash all over his body. The child had severe thrombocytopenia but was successfully treated with a single dose of intravenous immunoglobulin without complications. The study highlights that ITP post-MMR vaccine is an easily treatable condition.

摘要

免疫性血小板减少症(ITP)是一种在病毒感染后发生的自身免疫性疾病,也可能偶尔在麻疹、腮腺炎和风疹(MMR)疫苗接种后出现。ITP通常表现为在外表健康的儿童身上突然出现瘀点皮疹、瘀伤和/或出血。然而,MMR疫苗接种后的ITP通常不会导致血小板严重减少。我们报告一例13个月大男婴在接种MMR疫苗后发生ITP的病例,该患儿全身出现瘀点皮疹。患儿有严重血小板减少症,但通过单剂量静脉注射免疫球蛋白成功治愈,无并发症。该研究强调,MMR疫苗接种后发生的ITP是一种易于治疗的病症。