D'Orazio John A, Neely Jessica, Farhoudi Nina
Department of Pediatrics, Division of Hematology-Oncology and The Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY 40536-0096, USA.
J Pediatr Hematol Oncol. 2013 Jan;35(1):1-13. doi: 10.1097/MPH.0b013e318271f457.
Primary immune thrombocytopenia (ITP) is one of the most common bleeding disorders of childhood. In most cases, it presents with sudden widespread bruising and petechiae in an otherwise well child. Thought to be mainly a disorder of antibody-mediated platelet destruction, ITP can be self-limited or develop into a chronic condition. In this review, we discuss current concepts of the pathophysiology and treatment approaches to pediatric ITP.
原发性免疫性血小板减少症（ITP）是儿童期最常见的出血性疾病之一。在大多数情况下，它表现为原本健康的儿童突然出现广泛的瘀伤和瘀点。ITP被认为主要是一种抗体介导的血小板破坏疾病，可呈自限性或发展为慢性疾病。在本综述中，我们讨论了儿童ITP病理生理学和治疗方法的当前概念。
