食物过敏严重程度定义共识（DEFASE）：系统评价方案
Consensus on DEfinition of Food Allergy SEverity (DEFASE): Protocol for a systematic review.
作者信息
Arasi Stefania, Nurmatov Ulugbek, Turner Paul J, Ansotegui Ignacio J, Daher Shahd, Dunn-Galvin Audrey, Ebisawa Motohiro, Eigenmann Philippe, Fernandez-Rivas Montserrat, Gupta Ruchi, Nowak-Wegrzyn Anna, Petrou Stavros, Roberts Graham, Sánchez Borges Mario A, Sindher Sayantani B, Tanno Luciana Kase, Vazquez-Ortiz Marta, Vickery Brian P, Wong Gary Wing-Kin, Fiocchi Alessandro
机构信息
Predictive and Preventive Medicine Research Unit, Multifactorial and Systemic Diseases Research Area, Pediatric Allergology Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
Division of Population Medicine, School of Medicine, Cardiff University, Wales, UK.
出版信息
World Allergy Organ J. 2020 Dec 19;13(12):100493. doi: 10.1016/j.waojou.2020.100493. eCollection 2020 Dec.
BACKGROUND AND AIMS
The term "Food Allergy" refers to a complex global health problem with a wide spectrum of severity. However, a uniform definition of severe food allergy is currently missing. This systematic review is the preliminary step towards a state-of-the-art synopsis of the current evidence relating to the severity of IgE-mediated food allergy; it will inform attempts to develop a consensus to define food allergy severity by clinicians and other stakeholders.
METHODS
We will undertake a systematic review, which will involve searching international biomedical databases for published studies. Studies will be independently screened against pre-defined eligibility criteria and critically appraised by established instruments. Data will be descriptively and, if possible and applicable, quantitatively synthesised.
ETHICS AND DISSEMINATION
This study does not require any specific ethical approval since it is a systematic review. We plan to report results from this systematic review in a peer reviewed journal. These results will be used to inform the development of an international consensus to define severe food allergy. Author's potential conflicts of interest are clearly stated.
PROSPERO REGISTRATION NUMBER
CRD42020183103.
背景与目的
“食物过敏”一词指的是一个具有广泛严重程度范围的复杂全球健康问题。然而，目前缺乏对严重食物过敏的统一界定。本系统评价是迈向对当前与IgE介导的食物过敏严重程度相关证据的最新综述的初步步骤；它将为临床医生和其他利益相关者就制定食物过敏严重程度定义达成共识的尝试提供信息。
方法
我们将进行一项系统评价，包括在国际生物医学数据库中检索已发表的研究。研究将根据预先确定的纳入标准进行独立筛选，并通过既定工具进行严格评估。数据将进行描述性分析，如有可能且适用，将进行定量综合分析。
伦理与传播
本研究不需要任何特定的伦理批准，因为它是一项系统评价。我们计划在同行评审期刊上报告本系统评价的结果。这些结果将用于为制定国际严重食物过敏定义共识提供信息。作者潜在的利益冲突已明确声明。
PROSPERO注册号：CRD42020183103。
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